Das, Tanuza Song, Eun Joo Kim, Eunice EunKyeong 2024-01-19T14:34:11Z 2024-01-19T14:34:11Z 2022-01-10 2021-05 1661-6596 https://pubs.kist.re.kr/handle/201004/117021 Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator. English MDPI NF-KAPPA-B DEUBIQUITYLATING ENZYMES DEUBIQUITINATING ENZYMES COP9 SIGNALOSOME FUNCTIONAL-CHARACTERIZATION REVERSIBLE UBIQUITINATION STRUCTURAL BASIS PROTEASE USP15 INHIBITS P53 PEPTIDASE 15 The Multifaceted Roles of USP15 in Signal Transduction Article 10.3390/ijms22094728 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.9 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 9 scie scopus 000650352800001 2-s2.0-85105477773 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review NF-KAPPA-B DEUBIQUITYLATING ENZYMES DEUBIQUITINATING ENZYMES COP9 SIGNALOSOME FUNCTIONAL-CHARACTERIZATION REVERSIBLE UBIQUITINATION STRUCTURAL BASIS PROTEASE USP15 INHIBITS P53 PEPTIDASE 15 USP15 TGF-beta BMP NF-kappa B Wnt/beta-catenin CSN p53 IGF Nrf2-Keap1 RNA splicing