Park, Seul Gi Li, Mei-Xian Eom, Ji Hwan Suh, Eun Yeong Cho, Woo Kyung Joung, Yoon Ki Huh, Kang Moo 2024-01-19T14:34:16Z 2024-01-19T14:34:16Z 2022-01-10 2021-05 0379-153X https://pubs.kist.re.kr/handle/201004/117026 In this study, we developed self-crosslinkable and self-healing hydrogels by conjugating biocompatible and biodegradable glycol chitosan (GC) with biofunctional gallic acid (GA) and evaluated their potential application as a new tissue adhesive biomaterial. A series of GA-GC derivatives with different GA content were synthesized by varying the feed molar ratio of GA and their hydrogels were prepared via self-crosslinking reaction between pyrogallol groups of GA. The self-healing ability of GA-GC hydrogels was confirmed by rheological analysis, and their mechanical strength and tissue adhesion strength were observed to increase as the GA content of the hydrogels increased. The GA-GC hydrogels with biodegradability and low cytotoxicity would be useful as new tissue adhesive biomaterials. Korean POLYMER SOC KOREA FIBRIN ANTIOXIDANT PYROGALLOL HYDROGELS SEALANTS CHITIN Synthesis and Characterization of Gallic Acid Conjugated Glycol Chitosans for Tissue Adhesive Applications Article 10.7317/pk.2021.45.3.372 1 POLYMER-KOREA, v.45, no.3, pp.372 - 379 POLYMER-KOREA 45 3 372 379 scie scopus kci ART002717479 000654379200006 2-s2.0-85124417431 Polymer Science Polymer Science Article FIBRIN ANTIOXIDANT PYROGALLOL HYDROGELS SEALANTS CHITIN glycol chitosan gallic acid tissue adhesive application hydrogel self-crosslinking self-healing