Rahman, Md. Ataur Hannan, Md. Abdul Dash, Raju Rahman, MD. Hasanur Islam, Rokibul Uddin, Md Jamal Sohag, Abdullah Al Mamun Rahman, Md. Habibur Rhim, Hyewhon 2024-01-19T14:34:18Z 2024-01-19T14:34:18Z 2022-01-10 2021-05 1663-9812 https://pubs.kist.re.kr/handle/201004/117028 Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular pathways involved in the underlying pathobiology of cancer development and regulation. Pharmacological targeting of autophagy and apoptosis signaling using phytochemicals therefore offers a promising strategy that is complementary to conventional cancer chemotherapy. In this review, we sought to highlight the molecular basis of the autophagic-apoptotic pathway to understand its implication in the pathobiology of cancer, and explore this fundamental cellular process as a druggable anticancer target. We also aimed to present recent advances and address the limitations faced in the therapeutic development of phytochemical-based anticancer drugs. English Frontiers Media S.A. Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway Article 10.3389/fphar.2021.639628 1 Frontiers in Pharmacology, v.12 Frontiers in Pharmacology 12 Y scie scopus 000652500500001 2-s2.0-85106167533 Pharmacology & Pharmacy Pharmacology & Pharmacy Review CELL-CYCLE ARREST PROTECTIVE AUTOPHAGY CARCINOMA-CELLS OVARIAN-CANCER CATHEPSIN S KAPPA-B INHIBITION ROS SUPPRESSION PROGRESSION phytochemicals pharmacology apoptosis autophagy anticancer