Kim, Tae Hee Yan, Ji-Jing Jang, Joon Young Lee, Gwang-Min Lee, Sun-Kyung Kim, Beom Seok Chung, Justin J. Kim, Soo Hyun Jung, Youngmee Yang, Jaeseok 2024-01-19T15:00:29Z 2024-01-19T15:00:29Z 2021-09-05 2021-05 2375-2548 https://pubs.kist.re.kr/handle/201004/117079 Most of the vascular platforms currently being studied are lab-on-a-chip types that mimic capillary networks and are applied for vascular response analysis in vitro. However, these platforms have a limitation in clearly assessing the physiological phenomena of native blood vessels compared to in vivo evaluation. Here, we developed a simply fabricable tissue-engineered vascular microphysiological platform (TEVMP) with a three-dimensional (3D) vascular structure similar to an artery that can be applied for ex vivo and in vivo evaluation. Furthermore, we applied the TEVMP as ex vivo and in vivo screening systems to evaluate the effect of human CD200 (hCD200) overexpression in porcine endothelial cells (PECs) on vascular xenogeneic immune responses. These screening systems, in contrast to 2D in vitro and cellular xenotransplantation in vivo models, clearly demonstrated that hCD200 overexpression effectively suppressed vascular xenograft rejection. The TEVMP has a high potential as a platform to assess various vascular-related responses. English AMER ASSOC ADVANCEMENT SCIENCE ON-A-CHIP CD200 COMPRESSION PLATELET SURVIVAL BLOOD XENOTRANSPLANTATION GO Tissue-engineered vascular microphysiological platform to study immune modulation of xenograft rejection Article 10.1126/sciadv.abg2237 1 SCIENCE ADVANCES, v.7, no.22 SCIENCE ADVANCES 7 22 scie scopus 000655906900025 2-s2.0-85106998062 Multidisciplinary Sciences Science & Technology - Other Topics Article ON-A-CHIP CD200 COMPRESSION PLATELET SURVIVAL BLOOD XENOTRANSPLANTATION GO