Lee, Sangjun Park, Jimin Kwon, Jinuk Kim, Dong Hwan Im, Chang-Hwan 2024-01-19T15:00:31Z 2024-01-19T15:00:31Z 2021-09-05 2021-05 2045-2322 https://pubs.kist.re.kr/handle/201004/117081 Transorbital electrical stimulation (tES) has been studied as a new noninvasive method for treating intractable eye diseases by delivering weak electrical current to the eye through a pair of electrodes attached to the skin around the eye. Studies have reported that the therapeutic effect of tES is determined by the effective stimulation of retinal cells that are densely distributed in the posterior part of the retina. However, in conventional tES with a pair of electrodes, a greater portion of the electric field is delivered to the anterior part of the retina. In this study, to address this issue, a new electrode montage with multiple electrodes was proposed for the effective delivery of electric fields to the posterior retina. Electric field analysis based on the finite element method was performed with a realistic human head model, and optimal injection currents were determined using constrained convex optimization. The resultant electric field distributions showed that the proposed multi-channel tES enables a more effective stimulation of the posterior retina than the conventional tES with a pair of electrodes. English Nature Publishing Group Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina Article 10.1038/s41598-021-89243-y 1 Scientific Reports, v.11, no.1 Scientific Reports 11 1 Y scie scopus 000656463300006 2-s2.0-85105455997 Multidisciplinary Sciences Science & Technology - Other Topics Article ALTERNATING-CURRENT STIMULATION BRAIN-STIMULATION RESTORATION PIGMENTOSA VISION TDCS