Seo, Hyunseon Han, Sang Ihn Song, Kang-Il Seong, Duhwan Lee, Kyungwoo Kim, Sun Hong Park, Taesung Koo, Ja Hoon Shin, Mikyung Baac, Hyoung Won Park, Ok Kyu Oh, Soong Ju Han, Hyung-Seop Jeon, Hojeong Kim, Yu-Chan Kim, Dae-Hyeong Hyeon, Taeghwan Son, Donghee 2024-01-19T15:00:47Z 2024-01-19T15:00:47Z 2021-09-04 2021-05 0935-9648 https://pubs.kist.re.kr/handle/201004/117095 Soft neuroprosthetics that monitor signals from sensory neurons and deliver motor information can potentially replace damaged nerves. However, achieving long-term stability of devices interfacing peripheral nerves is challenging, since dynamic mechanical deformations in peripheral nerves cause material degradation in devices. Here, a durable and fatigue-resistant soft neuroprosthetic device is reported for bidirectional signaling on peripheral nerves. The neuroprosthetic device is made of a nanocomposite of gold nanoshell (AuNS)-coated silver (Ag) flakes dispersed in a tough, stretchable, and self-healing polymer (SHP). The dynamic self-healing property of the nanocomposite allows the percolation network of AuNS-coated flakes to rebuild after degradation. Therefore, its degraded electrical and mechanical performance by repetitive, irregular, and intense deformations at the device-nerve interface can be spontaneously self-recovered. When the device is implanted on a rat sciatic nerve, stable bidirectional signaling is obtained for over 5 weeks. Neural signals collected from a live walking rat using these neuroprosthetics are analyzed by a deep neural network to predict the joint position precisely. This result demonstrates that durable soft neuroprosthetics can facilitate collection and analysis of large-sized in vivo data for solving challenges in neurological disorders. English WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling Article 10.1002/adma.202007346 1 Advanced Materials, v.33, no.20 Advanced Materials 33 20 N scie scopus 000630445800001 2-s2.0-85102767271 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article conducting nanocomposites fatigue&#8208 resistant nanocomposites soft peripheral neuroprosthetics in vivo bidirectional signaling