Lee, K.H. Kim, J.K. Yu, J.S. Jeong, S.Y. Choi, J.H. Kim, J.-C. Ko, Y.-J. Kim, S.-H. Kim, K.H. 2024-01-19T15:01:05Z 2024-01-19T15:01:05Z 2021-09-02 2021-05 0253-6269 https://pubs.kist.re.kr/handle/201004/117106 Ginkgo biloba (Ginkgoaceae), commonly known as “ginkgo”, is called a living fossil, and it has been cultivated early in human history for various uses in traditional medicine and as a source of food. As part of ongoing research to explore the chemical diversity and biologically active compounds from natural resources, two new coumaric acid-aliphatic alcohol hybrids, ginkwanghols A (1) and B (2) were isolated from the leaves of G. biloba. The coumaric acid-aliphatic alcohol hybrids of natural products have rarely been reported. The structures of the new compounds were determined by extensive NMR spectroscopic analysis, HRESI-MS, and quantum chemical ECD calculations, and by comparing the experimental HRESI-MS/MS spectrum of chemically transformed compound 1a with the predicted HRESI-MS/MS spectra proposed from CFM-ID 3.0, a software tool for MS/MS spectral prediction and MS-based compound identification. Ginkwanghols A (1) and B (2) increased alkaline phosphatase (ALP) production in C3H10T1/2, a mouse mesenchymal stem cell line, in a dose-dependent manner. In addition, ginkwanghols A and B mediated the promotion of osteogenic differentiation as indicated by the induction of the mRNA expression of the osteogenic markers ALP and osteopontin (OPN). ？ 2021, The Pharmaceutical Society of Korea. English Pharmaceutical Society of Korea Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba Article 10.1007/s12272-021-01329-3 1 Archives of Pharmacal Research, v.44, no.5, pp.514 - 524 Archives of Pharmacal Research 44 5 514 524 scie scopus kci 000645873900001 2-s2.0-85105381079 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article Alkaline phosphatase CFM-ID 3.0 ECD calculations Ginkgo biloba MS/MS