Jegal, Jonghwan Park, No-June Jo, Beom-Geun Kim, Tae-Young Bong, Sim-Kyu Choi, Sangho Paik, Jin-Hyub Kim, Jung-Won Kim, Su-Nam Yang, Min Hye 2024-01-19T15:02:47Z 2024-01-19T15:02:47Z 2021-10-21 2021-04 1420-3049 https://pubs.kist.re.kr/handle/201004/117191 Plants of the genus Wikstroemia are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether Wikstroemia ganpi (Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of W. ganpi for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a W. ganpi ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that W. ganpi is a potential therapeutic agent for AD. English MDPI Wikstroemiaganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice Article 10.3390/molecules26072016 1 MOLECULES, v.26, no.7 MOLECULES 26 7 scie scopus 000638749900001 2-s2.0-85105143359 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article Wikstroemia ganpi atopic dermatitis 2 4-dinitrochlorobenzene immunoglobulin E interleukin-4