Son, Yang-Ju Shin, Ji Min Ha, In Jin Erdenebileg, Saruul Jung, Da Seul Kim, Young Sik Kim, Sang Min Nho, Chu Won 2024-01-19T15:03:41Z 2024-01-19T15:03:41Z 2021-09-02 2021-04 0192-415X https://pubs.kist.re.kr/handle/201004/117237 Artemisia gmelinii Web. ex Stechm. (AG), a popular medicinal herb in Asia, has been used as a common food ingredient in Korea and is traditionally known for its anti-inflammatory properties. Therefore, in this study, we aimed to investigate whether AG relieves IBD, a classic chronic inflammatory disease of the gastrointestinal tract. We identified 35 chemical compounds in AG ethanol extract using ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. In mice with DSS-induced IBD, AG administration attenuated the disease activity index and the serum and colonic levels of inflammatory cytokines and chemokines. AG treatment decreased nuclear factor-kappa B (NF-kappa B) signaling, a key mediator of inflammation, in the mouse colons. Additionally, AG extract enhanced immune responses in lymphoid tissues such as spleen and Peyer's patches. Thus, AG consumption potently ameliorated IBD symptoms and improved immune signaling in lymphoid tissues. English WORLD SCIENTIFIC PUBL CO PTE LTD NF-KAPPA-B INFLAMMATORY-BOWEL-DISEASE TRANSCRIPTION FACTOR DENDRITIC CELLS T-CELLS IBD SCOPOLETIN SPLEEN IL-10 PATHOGENESIS Identification of Chemical Compounds from Artemisia gmelinii using UPLC-QTOF-MS/MS and their Regulatory Effects on Immune Responses in DSS-Induced Colitis Mice Article 10.1142/S0192415X21500452 1 AMERICAN JOURNAL OF CHINESE MEDICINE, v.49, no.04, pp.941 - 963 AMERICAN JOURNAL OF CHINESE MEDICINE 49 04 941 963 scie scopus 000647483500009 2-s2.0-85103985182 Integrative & Complementary Medicine Medicine, General & Internal Integrative & Complementary Medicine General & Internal Medicine Article NF-KAPPA-B INFLAMMATORY-BOWEL-DISEASE TRANSCRIPTION FACTOR DENDRITIC CELLS T-CELLS IBD SCOPOLETIN SPLEEN IL-10 PATHOGENESIS Artemisia gmelinii Web ex Stechm Chemical Profiling UPLC-QTOF-MS/MS Inflammatory Bowel Disease Immune System Inflammatory Response Colon