Jin, Jong Beom Cha, Jin Wook Shin, Il-Shik Jeon, Jin Young An, Hye Suck Cha, Kwang Hyun Pan, Cheol-Ho 2024-01-19T15:04:34Z 2024-01-19T15:04:34Z 2022-01-28 2021-03 1976-0442 https://pubs.kist.re.kr/handle/201004/117282 The diet plays a fundamental role in the formation of the gut microbiota, determining the interrelationship between the gut microbiota and the host. The current study investigated the effect of Chlorella vulgaris on the gut microbiota by using simulated in vitro digestion and colonic fermentation. Bioaccessibility was measured after in vitro digestion, and SCFAs and microbial profiling were analyzed after colonic fermentation. The bioaccessibility of C. vulgaris was 0.24 g/g. The three major SCFAs (acetate, propionate, and butyrate) increased significantly when compared to the control group. In microbial profiling analysis, microorganisms such as Faecalibacterium, Dialister, Megasphaera, Dorea, Odoribacter, Roseburia, Bifidobacterium, Butyricmonas, and Veillonella were high in C. vulgaris group. Among them, Faecalibacterium, Dialister, Megasphaera, Roseburia, and Veillonella were thought to be closely associated with the increased level of SCFAs. Finally, it can be expected to help improve gut microbiota and health through ingestion of C. vulgaris. However, further studies are vital to confirm the changes in the gut microbiota in in vivo, when C. vulgaris is ingested. ？ 2021, Korean Society for Applied Biological Chemistry. All rights reserved. English 한국응용생명화학회 Effect of chlorella vulgaris on gut microbiota through a simulated in vitro digestion process Article 10.3839/jabc.2021.008 1 Journal of Applied Biological Chemistry, v.64, no.1, pp.49 - 55 Journal of Applied Biological Chemistry 64 1 49 55 N scopus kci 2-s2.0-85104313166 Article Bioaccessibility Gut microbiota Microbial profiling Short chain fatty acids