Hur, Joonseong Jang, Jaebong Sim, Jaehoon 2024-01-19T15:04:37Z 2024-01-19T15:04:37Z 2022-01-25 2021-03 1661-6596 https://pubs.kist.re.kr/handle/201004/117284 gamma-Butyrolactone, a five-membered lactone moiety, is one of the privileged structures of diverse natural products and biologically active small molecules. Because of their broad spectrum of biological and pharmacological activities, synthetic methods for gamma-butyrolactones have received significant attention from synthetic and medicinal chemists for decades. Recently, new developments and improvements in traditional methods have been reported by considering synthetic efficiency, feasibility, and green chemistry. In this review, the pharmacological activities of natural and synthetic gamma-butyrolactones are described, including their structures and bioassay methods. Mainly, we summarize recent advances, occurring during the past decade, in the construction of gamma-butyrolactone classified based on the bond formation in gamma-butyrolactone between (i) C5-O1 bond, (ii) C4-C5 and C2-O1 bonds, (iii) C3-C4 and C2-O1 bonds, (iv) C3-C4 and C5-O1 bonds, (v) C2-C3 and C2-O1 bonds, (vi) C3-C4 bond, and (vii) C2-O1 bond. In addition, the application to the total synthesis of natural products bearing gamma-butyrolactone scaffolds is described. English MDPI A Review of the Pharmacological Activities and Recent Synthetic Advances of gamma-Butyrolactones Article 10.3390/ijms22052769 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.5 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 5 N scie scopus 000628287300001 2-s2.0-85102103889 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review &#947 -butyrolactone pharmacological activities lactone synthesis lactonization recent advances