Rahman, Md Ataur Dash, Raju Sohag, Abdullah Al Mamun Alam, Mahboob Ha, Hunjoo Moon, Il Soo Uddin, Md Jamal Hannan, Md Abdul Rhim, Hyewhon 2024-01-19T15:05:01Z 2024-01-19T15:05:01Z 2022-01-10 2021-03 1660-3397 https://pubs.kist.re.kr/handle/201004/117305 Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer's agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer's activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD. English Multidisciplinary Digital Publishing Institute (MDPI) Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances Article 10.3390/md19030167 1 Marine Drugs, v.19, no.3 Marine Drugs 19 3 Y scie scopus 000633856900001 2-s2.0-85103919968 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Review CHOLESTEROL ABSORPTION ANTIOXIDANT ACTIVITIES ECKLONIA-STOLONIFERA UNDARIA-PINNATIFIDA SARGASSUM-FUSIFORME EISENIA-BICYCLIS BROWN-ALGAE MOUSE MODEL FUCOSTEROL PHYTOSTEROLS cholesterol homeostasis marine steroids fucosterol neurodegeneration inflammation oxidative stress