Han, Seong Jae Jun, Jimoon Eyun, Seong-il Lee, Choong-Gu Jeon, Jimin Pan, Cheol-Ho 2024-01-19T15:05:35Z 2024-01-19T15:05:35Z 2021-09-05 2021-03 1424-8247 https://pubs.kist.re.kr/handle/201004/117339 Schisandrol A possesses pharmacological properties and is used to treat various diseases; however, its effects on osteoarthritis (OA) progression remain unclear. Here, we investigated Schisandrol A as a potential therapeutic agent for OA. In vitro, Schisandrol A effects were confirmed based on the levels of expression of catabolic factors (MMPs, ADAMTS5, and Cox2) induced by IL-1 beta or Schisandrol A treatment in chondrocytes. In vivo, experimental OA in mice was induced using a destabilized medial meniscus (DMM) surgical model or oral gavage of Schisandrol A in a dose-dependent manner, and demonstrated using histological analysis. In vitro and in vivo analyses demonstrated that Schisandrol A inhibition attenuated osteoarthritic cartilage destruction via the regulation of Mmp3, Mmp13, Adamts5, and Cox2 expression. In the NF-kappa B signaling pathway, Schisandrol A suppressed the degradation of I kappa B and the phosphorylation of p65 induced by IL-1 beta. Overall, and Schisandrol A reduced the expression of catabolic factors by blocking NF-kappa B signaling and prevented cartilage destruction. Therefore, Schisandrol A attenuated OA progression, and can be used to develop novel OA drug therapies. English MDPI Schisandrol A Suppresses Catabolic Factor Expression by Blocking NF-kappa B Signaling in Osteoarthritis Article 10.3390/ph14030241 1 PHARMACEUTICALS, v.14, no.3 PHARMACEUTICALS 14 3 scie scopus 000634051100001 2-s2.0-85103037345 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article MATRIX METALLOPROTEINASES ARTICULAR-CARTILAGE INFLAMMATION CHONDROCYTES PATHOGENESIS DEGRADATION GENE MODEL INTERLEUKIN-1 INHIBITION Schisandrol A cartilage destruction osteoarthritis NF-kappa B