Kim, D.-E. Kim, M.-S. An, H.S. Lee, J.W. Park, J.-S. 2024-01-19T15:31:32Z 2024-01-19T15:31:32Z 2022-01-28 2021-02 1976-0442 https://pubs.kist.re.kr/handle/201004/117431 Marine sponges contain pharmacologically attractive substances that exhibit strong cytotoxicity and are used as materials to isolate potential drug candidates. However, with a growing interest in marine ecosystem conservation, it is becoming increasingly difficult to gather a sponge for natural product research. To build a database to cope with this issue, we measured the neuroprotective and anti-inflammatory activity of 181 sponge extracts. As a result, we found 17 samples with neuroprotective effects and 14 samples with anti-inflammatory effects. In addition, high-performance liquid chromatography (HPLC) analysis was performed to compare the components contained in each sample, and based on HPLC profiles, a dendrogram according to similarity was created. The results of this study suggested the possibility of discovering the active compounds in the sponge and laid the basis for efficient research on the sponge. ？ 2021, Korean Society for Applied Biological Chemistry. All rights reserved. Korean Korean Society for Applied Biological Chemistry Neuroprotective and anti-inflammatory activity of marine sponge extract and HPLC profiling of its components Article 10.3839/jabc.2021.006 1 Journal of Applied Biological Chemistry, v.64, no.1, pp.33 - 38 Journal of Applied Biological Chemistry 64 1 33 38 scopus kci ART002695916 2-s2.0-85104303732 Article Anti-inflammatory activity High-performance liquid chromatography profiling Neuroprotective activity Sponge