Nassir, Che Mohd Nasril Che Mohd Ghazali, Mazira Mohamad Hashim, Sabarisah Idris, Nur Suhaila Yuen, Lee Si Hui, Wong Jia Norman, Haziq Hazman Gau, Chuang Huei Jayabalan, Nanthini Na, Yuri Feng, Linqing Ong, Lin Kooi Hamid, Hafizah Abdul Ahamed, Haja Nazeer Mustapha, Muzaimi 2024-01-19T15:31:36Z 2024-01-19T15:31:36Z 2022-01-25 2021-02 2297-055X https://pubs.kist.re.kr/handle/201004/117434 Cerebral small vessel disease (CSVD) represents a spectrum of pathological processes of various etiologies affecting the brain microcirculation that can trigger neuroinflammation and the subsequent neurodegenerative cascade. Prevalent with aging, CSVD is a recognized risk factor for stroke, vascular dementia, Alzheimer disease, and Parkinson disease. Despite being the most common neurodegenerative condition with cerebrocardiovascular axis, understanding about it remains poor. Interestingly, modifiable risk factors such as unhealthy diet including high intake of processed food, high-fat foods, and animal by-products are known to influence the non-neural peripheral events, such as in the gastrointestinal tract and cardiovascular stress through cellular inflammation and oxidation. One key outcome from such events, among others, includes the cellular activations that lead to elevated levels of endogenous cellular-derived circulating microparticles (MPs). MPs can be produced from various cellular origins including leukocytes, platelets, endothelial cells, microbiota, and microglia. MPs could act as microthrombogenic procoagulant that served as a plausible culprit for the vulnerable end-artery microcirculation in the brain as the end-organ leading to CSVD manifestations. However, little attention has been paid on the potential role of MPs in the onset and progression of CSVD spectrum. Corroboratively, the formation of MPs is known to be influenced by diet-induced cellular stress. Thus, this review aims to appraise the body of evidence on the dietary-related impacts on circulating MPs from non-neural peripheral origins that could serve as a plausible microthrombosis in CSVD manifestation as a precursor of neurodegeneration. Here, we elaborate on the pathomechanical features of MPs in health and disease states; relevance of dietary patterns on MP release; preclinical studies pertaining to diet-based MPs contribution to disease; MP level as putative surrogates for early disease biomarkers; and lastly, the potential of MPs manipulation with diet-based approach as a novel preventive measure for CSVD in an aging society worldwide. English FRONTIERS MEDIA SA Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease Article 10.3389/fcvm.2021.632131 1 FRONTIERS IN CARDIOVASCULAR MEDICINE, v.8 FRONTIERS IN CARDIOVASCULAR MEDICINE 8 N scie scopus 000626740400001 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Review STOP HYPERTENSION DASH POLYUNSATURATED FATTY-ACIDS ENDOTHELIAL PROGENITOR CELLS REFINED GRAIN CONSUMPTION TYPE-2 DIABETES-MELLITUS CORONARY-ARTERY-DISEASE WHITE-MATTER LESIONS ALPHA-LINOLENIC ACID ACUTE KIDNEY INJURY MEDITERRANEAN DIET cerebral small vessel disease diet microparticles neurodegeneration microthrombosis