Woo, JunHyuk Cho, Hyesun Seol, YunHee Kim, Soon Ho Park, Chanhyeok Yousefian-Jazi, Ali Hyeon, Seung Jae Lee, Junghee Ryu, Hoon 2024-01-19T15:31:45Z 2024-01-19T15:31:45Z 2022-01-10 2021-02 2076-3921 https://pubs.kist.re.kr/handle/201004/117442 The brain needs more energy than other organs in the body. Mitochondria are the generator of vital power in the living organism. Not only do mitochondria sense signals from the outside of a cell, but they also orchestrate the cascade of subcellular events by supplying adenosine-5 '-triphosphate (ATP), the biochemical energy. It is known that impaired mitochondrial function and oxidative stress contribute or lead to neuronal damage and degeneration of the brain. This mini-review focuses on addressing how mitochondrial dysfunction and oxidative stress are associated with the pathogenesis of neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease. In addition, we discuss state-of-the-art computational models of mitochondrial functions in relation to oxidative stress and neurodegeneration. Together, a better understanding of brain disease-specific mitochondrial dysfunction and oxidative stress can pave the way to developing antioxidant therapeutic strategies to ameliorate neuronal activity and prevent neurodegeneration. English MDPI Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models Article 10.3390/antiox10020229 1 ANTIOXIDANTS, v.10, no.2 ANTIOXIDANTS 10 2 scie scopus 000622056900001 2-s2.0-85100543651 Biochemistry & Molecular Biology Chemistry, Medicinal Food Science & Technology Biochemistry & Molecular Biology Pharmacology & Pharmacy Food Science & Technology Review mitochondria oxidative stress antioxidants Alzheimer&#8217 s disease amyotrophic lateral sclerosis Huntington&#8217 s disease Parkinson&#8217 s disease computational modeling