Jin, Hyung-Seung Park, Yoon 2024-01-19T15:32:39Z 2024-01-19T15:32:39Z 2021-09-02 2021-01-31 1976-6696 https://pubs.kist.re.kr/handle/201004/117497 Antibody-based therapeutics targeting the inhibitory receptors PD-1, PD-L1, or CTLA-4 have shown remarkable clinical progress on several cancers. However, most patients do not benefit from these therapies. Thus, many efforts are being made to identify new immune checkpoint receptor-ligand pathways that are alternative targets for cancer immunotherapies. Nectin and nectin-like molecules are widely expressed on several types of tumor cells and play regulatory roles in T- and NK-cell functions. TIGIT, CD226, CD96 and CD112R on lymphoid cells are a group of immunoglobulin superfamily receptors that interact with Nectin and nectin-like molecules with different affinities. These receptors transmit activating or inhibitory signals upon binding their cognate ligands to the immune cells. The integrated signals formed by their complex interactions contribute to regulating immune-cell functions. Several clinical trials are currently evaluating the efficacy of anti-TIGIT and anti-CD112R blockades for treating patients with solid tumors. However, many questions still need to be answered in order to fully understand the dynamics and functions of these receptor networks. This review addresses the rationale behind targeting TIGIT, CD226, CD96, and CD112R to regulate T- and NK-cell functions and discusses their potential application in cancer immunotherapy. English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY ACTIVATING RECEPTOR CD226 NECTIN-LIKE PROTEINS NK CELL RECOGNITION CARCINOMA CELLS T-CELLS TIGIT DNAM-1 ADHESION CD155 CHECKPOINT Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy Article 10.5483/BMBRep.2021.54.1.229 1 BMB REPORTS, v.54, no.1, pp.2 - 11 BMB REPORTS 54 1 2 11 scie scopus kci other ART002680581 000614268100002 2-s2.0-85100373572 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Review ACTIVATING RECEPTOR CD226 NECTIN-LIKE PROTEINS NK CELL RECOGNITION CARCINOMA CELLS T-CELLS TIGIT DNAM-1 ADHESION CD155 CHECKPOINT Cancer immunotherapy CD112R CD226 CD96 TIGIT