Sharif, Farnaz Tayebi, Behnam Buzsaki, Gyorgy Royer, Sebastien Fernandez-Ruiz, Antonio 2024-01-19T15:32:53Z 2024-01-19T15:32:53Z 2021-09-02 2021-01-20 0896-6273 https://pubs.kist.re.kr/handle/201004/117513 The hippocampus is thought to guide navigation by forming a cognitive map of space. Different environments differ in geometry and the availability of cues that can be used for navigation. Although several spatial coding mechanisms are known to coexist in the hippocampus, how they are influenced by various environmental features is not well understood. To address this issue, we examined the spatial coding characteristics of hippocampal neurons in mice and rats navigating in different environments. We found that CA1 place cells located in the superficial sublayer were more active in cue-poor environments and preferentially used a firing rate code driven by intra-hippocampal inputs. In contrast, place cells located in the deep sublayer were more active in cue-rich environments and used a phase code driven by entorhinal inputs. Switching between these two spatial coding modes was supported by the interaction between excitatory gamma inputs and local inhibition. English CELL PRESS LOCAL-FIELD POTENTIALS GAMMA OSCILLATIONS INTRINSIC CIRCUITRY ENTORHINAL CORTEX PHASE PRECESSION PYRAMIDAL CELLS DYNAMICS HIPPOCAMPUS INPUT ORGANIZATION Subcircuits of Deep and Superficial CA1 Place Cells Support Efficient Spatial Coding across Heterogeneous Environments Article 10.1016/j.neuron.2020.10.034 1 NEURON, v.109, no.2, pp.363 - + NEURON 109 2 363 + scie scopus 000613535400003 2-s2.0-85097247807 Neurosciences Neurosciences & Neurology Article LOCAL-FIELD POTENTIALS GAMMA OSCILLATIONS INTRINSIC CIRCUITRY ENTORHINAL CORTEX PHASE PRECESSION PYRAMIDAL CELLS DYNAMICS HIPPOCAMPUS INPUT ORGANIZATION CA1 sublayers gamma oscillations hippocampus phase code phase precession place cells rate code spatial navigation theta rhythm theta sequences