Ahn, Sungeun Simu, Shakina Yesmin Yang, Deok-Chun Jang, Mi Um, Byung-Hun 2024-01-19T15:33:28Z 2024-01-19T15:33:28Z 2022-01-10 2021-01-01 0954-0105 https://pubs.kist.re.kr/handle/201004/117549 Inflammatory bowel disease (IBD) is a critical disorder characterized by chronic inflammation of the gastrointestinal tract, primarily the small intestine and colon, which eventually leads to disruption of the gut barrier function. Panax ginseng (P. ginseng) is an important traditional herb, which contains various active constituents known as ginsenosides. Ginsenoside Rf (Rf) is a dynamic component of P. ginseng and is rarely available in other species. This study determined the anti-inflammatory effects of Rf in a dextran sodium sulfate (DSS)-induced colitis mouse model. The results demonstrated significantly lower body weight loss and shortening of colon length in mice treated with Rf than in DSS-treated mice. In addition, inflammatory signalling mechanisms involving interleukin-6 and tumour necrosis factor-alpha were inhibited in Rf-treated mice. The results suggest Rf as a potential anti-inflammatory agent that can be used for the treatment of IBD. English TAYLOR & FRANCIS LTD INFLAMMATORY-BOWEL-DISEASE MEDICINAL-PLANTS NATURAL-PRODUCTS PANAX-GINSENG KAPPA-B Effects of Ginsenoside Rf on dextran sodium sulfate-induced colitis in mice Article 10.1080/09540105.2021.1950128 1 FOOD AND AGRICULTURAL IMMUNOLOGY, v.32, no.1, pp.360 - 372 FOOD AND AGRICULTURAL IMMUNOLOGY 32 1 360 372 scie scopus 000682853100001 2-s2.0-85112490220 Chemistry, Applied Food Science & Technology Immunology Toxicology Chemistry Food Science & Technology Immunology Toxicology Article INFLAMMATORY-BOWEL-DISEASE MEDICINAL-PLANTS NATURAL-PRODUCTS PANAX-GINSENG KAPPA-B Inflammation inflammatory bowel disease Ginsenoside Rf NF-kappa B