Kim, Hyosuk Kim, Eun Hye Kwak, Gijung Chi, Sung-Gil Kim, Sun Hwa Yang, Yoosoo 2024-01-19T15:34:01Z 2024-01-19T15:34:01Z 2022-01-10 2021-01 1661-6596 https://pubs.kist.re.kr/handle/201004/117580 Exosomes are cell-secreted nanovesicles that naturally contain biomolecular cargoes such as lipids, proteins, and nucleic acids. Exosomes mediate intercellular communication, enabling the transfer biological signals from the donor cells to the recipient cells. Recently, exosomes are emerging as promising drug delivery vehicles due to their strong stability in blood circulation, high biocompatibility, low immunogenicity, and natural targeting ability. In particular, exosomes derived from specific types of cells can carry endogenous signaling molecules with therapeutic potential for cancer treatment, thus presenting a significant impact on targeted drug delivery and therapy. Furthermore, exosomes can be engineered to display targeting moieties on their surface or to load additional therapeutic agents. Therefore, a comprehensive understanding of exosome biogenesis and the development of efficient exosome engineering techniques will provide new avenues to establish convincing clinical therapeutic strategies based on exosomes. This review focuses on the therapeutic applications of exosomes derived from various cells and the exosome engineering technologies that enable the accurate delivery of various types of cargoes to target cells for cancer therapy. English MDPI Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics Article 10.3390/ijms22010014 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 1 scie scopus 000606658400001 2-s2.0-85098513756 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review extracellular vesicle exosome cancer therapeutic drug delivery exosome engineering