Mondal, Abhijit Ha, Junhyoung Jo, Vickie Y. Wu, Fei-Yi Kaza, Aditya K. Dupont, Pierre E. 2024-01-19T15:34:27Z 2024-01-19T15:34:27Z 2021-09-02 2021-01 0022-5223 https://pubs.kist.re.kr/handle/201004/117606 Objectives: We sought to demonstrate in an animal model that helical stents made from a nickel titanium alloy called nitinol (NiTi) and designed for malacic airways could be delivered and removed without significant trauma while minimally impeding mucus clearance during the period of implantation. Methods: Stents were delivered and removed from the tracheas of healthy 20 kg swine (n = 5) using tools designed to minimize trauma. In 4-week experiments, the stents were implanted on day o, removed after 3 weeks, and swine were put to death after 4 weeks. Weekly bronchoscopies, radiographs, and mucus clearance examinations were performed in vivo. Hematoxylin and eosin staining and scanning electron microscopy imaging were used to evaluate foreign body response, tracheal tissue reaction, and damage and to measure unciliated regions. Results: In all in vivo experiments, the stent was implanted and removed atraumatically. Mucus clearance was maintained throughout the experiment period. Hematoxylin and eosin-stained slides showed that foreign body response and tracheal tissue damage were localized to the stented subsections. Tracheal tissue reaction and damage was further restricted to the epithelium and submucosal layers. Scanning electron microscopy imaging revealed that the cilia were absent only over the contact area between the trachea and the wire forming the helical stent. Conclusions: Helical nitinol stents designed to provide radial support for malacic airways were well tolerated in a porcine model, providing for mucus clearance while also enabling atraumatic removal. English MOSBY-ELSEVIER SILICONE STENTS CHILDREN INFANTS OBSTRUCTION EXPERIENCE MANAGEMENT PRESSURE Preclinical evaluation of a pediatric airway stent for tracheobronchomalacia Article 10.1016/j.jtcvs.2020.03.007 1 JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, v.161, no.1, pp.E51 - E60 JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 161 1 E51 E60 scie scopus 000608500200027 2-s2.0-85083639990 Cardiac & Cardiovascular Systems Respiratory System Surgery Cardiovascular System & Cardiology Respiratory System Surgery Article SILICONE STENTS CHILDREN INFANTS OBSTRUCTION EXPERIENCE MANAGEMENT PRESSURE tracheobronchomalacia airway stent preclinical validation