Seo, Moon Young Choi, Man Ho Hong, Youngmin Kim, Shin-Hye Park, Mi Jung 2024-01-19T16:00:34Z 2024-01-19T16:00:34Z 2021-09-02 2021-01 0944-1344 https://pubs.kist.re.kr/handle/201004/117659 This study aimed to assess the association between urinary concentrations of chlorophenols and childhood central obesity. The study subjects were 165 girls (91 with central obesity and 74 with non-central obesity) aged 7-8 years who visited a hospital for regular health check-ups. The urinary concentrations of chlorophenols including 2,4-dichlorophenol (2,4-DCP), 2,5-dichlorophenol (2,5-DCP), 2,4,5-trichlorophenol (2,4,5-TCP), and 2,4,6-trichlorophenol (2,4,6-TCP) were analyzed using liquid chromatography-tandem mass spectrometry. The central obesity group showed significantly higher urinary concentrations of 2,5-DCP (0.56 vs. 0.28 ng/mL) and 2,4,5-TCP (0.06 vs. 0.03 ng/mL) than the non-central obesity group. The sum of molar concentrations of urinary chlorophenols was also significantly higher in the central obesity group than in the non-central obesity group (9.83 vs. 5.26 nmol/L). Girls in the highest quartile of the molar sum of chlorophenols showed significantly higher body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) compared with the lowest quartile after adjusting for covariates. WC and WHtR, but not BMI, were significantly associated with higher quartiles of the molar sum of chlorophenols (P-for-trend = 0.025 and 0.028, respectively). We found a positive association between chlorophenol exposure and central obesity in Korean girls. Large-scale prospective studies are needed to confirm our findings. English SPRINGER HEIDELBERG DICHLOROPHENOL PESTICIDES CARDIOMETABOLIC RISK CHLORINATED PHENOLS EXCRETION CHILDREN HEALTH METABOLISM PARABENS Association of urinary chlorophenols with central obesity in Korean girls Article 10.1007/s11356-020-10628-z 1 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, v.28, no.2, pp.1966 - 1972 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 28 2 1966 1972 scie scopus 000563729700004 2-s2.0-85089983218 Environmental Sciences Environmental Sciences & Ecology Article DICHLOROPHENOL PESTICIDES CARDIOMETABOLIC RISK CHLORINATED PHENOLS EXCRETION CHILDREN HEALTH METABOLISM PARABENS Chlorophenols Central obesity Waist circumference Waist-to-height ratio Body mass index Girl Korea