Rahman, Md Ataur Rahman, Md Saidur Uddin, Md Jamal Mamum-Or-Rashid, A. N. M. Pang, Myung-Geol Rhim, Hyewhon 2024-01-19T16:01:46Z 2024-01-19T16:01:46Z 2022-01-10 2020-12 0944-1344 https://pubs.kist.re.kr/handle/201004/117729 Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements. Latest observations have hypothesized that exposure of environmental factors may increase the prospective risk of Alzheimer's diseases (AD). However, the role of environmental factors as a possible dangerous issue has extended importance concerned in AD pathology, although actual etiology of the disorder is still not yet clear. Thus, the aim of this review is to highlight the possible correlation between environmental factors and AD, based on the present literature view. Environmental risk factors might play an important role in decelerating or accelerating AD progression. Among well-known environmental risk factors, prolonged exposure to several heavy metals, for example, aluminum, arsenic, cadmium, lead, and mercury; particulate air, and some pesticides as well as metal-containing nanoparticles have been participated to cause AD. These heavy metals have the capacity to enhance amyloid beta (A beta) peptide along with tau phosphorylation, initiating amyloid/senile plaques, as well as neurofibrillary tangle formation; therefore, neuronal cell death has been observed. Furthermore, particulate air, pesticides, and heavy metal exposure have been recommended to lead AD susceptibility and phenotypic diversity though epigenetic mechanisms. Therefore, this review deliberates recent findings detailing the mechanisms for a better understanding the relationship between AD and environmental risk factors along with their mechanisms of action on the brain functions. English Springer Verlag Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases Article 10.1007/s11356-020-08243-z 1 Environmental Science and Pollution Research, v.27, no.36, pp.44659 - 44672 Environmental Science and Pollution Research 27 36 44659 44672 N scie scopus 000521142700001 2-s2.0-85082857998 Environmental Sciences Environmental Sciences & Ecology Article MILD COGNITIVE IMPAIRMENT A-BETA ACCUMULATION BLOOD-BRAIN-BARRIER PP SWEDISH MICE OXIDATIVE STRESS TAU PHOSPHORYLATION NEURODEGENERATIVE DISEASES ENGINEERED NANOPARTICLES HIPPOCAMPAL NEUROGENESIS AMYLOID PRECURSOR PROTEIN Alzheimer&apos s diseases Environmental factors Amyloid beta Tau phosphorylation