Du, Ji Eun You, Young Ah Kwon, Eun Jin Kim, Soo Min Lee, Jeongae Han, Ki Hwan Kim, Young Ju 2024-01-19T16:02:11Z 2024-01-19T16:02:11Z 2021-09-02 2020-12 1661-6596 https://pubs.kist.re.kr/handle/201004/117754 Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet-related alterations in metabolites and the biological pathway in male offspring at three months of age. Pregnant rats were exposed to 50% food restriction during the prenatal period or a 45% high-fat diet during the prenatal and postnatal periods. The male offspring exposed to food restriction and high-fat diets had lower birth weights than controls, but had a catch-up growth spurt at three months of age. Hepatic taurine levels decreased in both groups compared to controls. The decreased hepatic taurine levels in offspring affected excessive lipid accumulation through changes in hepatocyte nuclear factor 4 A methylation. Moreover, the alteration of gluconeogenesis in offspring exposed to food restriction was observed to a similar extent as that of offspring exposed to a high fat diet. These results indicate that maternal diet affects the dysregulation in hepatic metabolism through changes in taurine levels and HNF4A methylation, and predisposes the offspring to Type 2 diabetes and non-alcoholic fatty liver disease in later life. English Multidisciplinary Digital Publishing Institute (MDPI) Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation Article 10.3390/ijms21239060 1 International Journal of Molecular Sciences, v.21, no.23 International Journal of Molecular Sciences 21 23 Y scie scopus 000597487500001 2-s2.0-85096824643 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article fetal programming food restriction high fat diet taurine HNF4A methylation