Lee, Yijae Lee, Changhyuk Wang, Eun Jin Kotov, Dmytro Kim, Hee Youn Hwang, Jeong Ho Ahn, Ki Hoon Lee, Soo Hyun 2024-01-19T16:02:14Z 2024-01-19T16:02:14Z 2021-09-02 2020-12 1534-4320 https://pubs.kist.re.kr/handle/201004/117758 Preterm labor and birth are the primary causes of neonatal morbidities and mortalities. The early detection and treatment of preterm uterine muscular contraction are crucial for the management of preterm labor. In this work, a ring electrode with a wireless electrical recording and stimulating (RE-WERS) system was designed, fabricated, and investigated for the non-invasive monitoring of uterine contraction/relaxation as a diagnostic and therapeutic tool for preterm labor. By using an organ bath system, we confirmed that the uterine contraction force in mice can be decreased by the application of electrical stimulation. Then, the RE-WERS system was inserted non-invasively through the vagina to the cervix of a pregnant minipig, and it successfully recorded the uterine contraction and reflect signals when various electrical stimulating conditions were applied. The difference in the uterine signals before and after the injection of a labor induction drug, such as oxytocin and prostaglandin F2 alpha, was recorded, and the difference was remarkable. In addition, the uterine signal that was recorded was well matched with the signal of the electromyography (EMG) kit during open abdominal surgery. It seemed that the continuous and various electrical stimulations affected the delay or inhibition of childbirth in the pregnant minipig. English Institute of Electrical and Electronics Engineers Non-Invasive Ring Electrode With a Wireless Electrical Recording and Stimulating System for Monitoring Preterm Labor Article 10.1109/TNSRE.2020.3032742 1 IEEE Transactions on Neural Systems and Rehabilitation Engineering, v.28, no.12, pp.2627 - 2636 IEEE Transactions on Neural Systems and Rehabilitation Engineering 28 12 2627 2636 N scie scopus 000613615700005 2-s2.0-85098751685 Engineering, Biomedical Rehabilitation Engineering Rehabilitation Article Electrodes Wireless communication Pregnancy Electrical stimulation Data acquisition Gain Band-pass filters Preterm labor Noninvasive RE-WERS electrical stimulation recording