Lee, Yu Ra An, Ki-Yong Jeon, Justin Kim, Nam Kyu Lee, Ji Won Hong, Jongki Chung, Bong Chul 2024-01-19T16:02:26Z 2024-01-19T16:02:26Z 2021-09-02 2020-12 2218-1989 https://pubs.kist.re.kr/handle/201004/117770 Colorectal cancer is one of the most prevalent cancers in Korea and globally. In this study, we aimed to characterize the differential serum metabolomic profiles between pre-operative and post-operative patients with colorectal cancer. To investigate the significant metabolites and metabolic pathways associated with colorectal cancer, we analyzed serum samples from 68 patients (aged 20-71, mean 57.57 years). Untargeted and targeted metabolomics profiling in patients with colorectal cancer were performed using liquid chromatography-mass spectrometry. Untargeted analysis identified differences in sphingolipid metabolism, steroid biosynthesis, and arginine and proline metabolism in pre- and post-operative patients with colorectal cancer. We then performed quantitative target profiling of polyamines, synthesized from arginine and proline metabolism, to identify potential polyamines that may serve as effective biomarkers for colorectal cancer. Results indicate a significantly reduced serum concentration of putrescine in post-operative patients compared to pre-operative patients. Our metabolomics approach provided insights into the physiological alterations in patients with colorectal cancer after surgery. English MDPI CELL-PROLIFERATION PUTRESCINE PROLINE GROWTH TISSUE METABOLISM Untargeted Metabolomics and Polyamine Profiling in Serum before and after Surgery in Colorectal Cancer Patients Article 10.3390/metabo10120487 1 METABOLITES, v.10, no.12 METABOLITES 10 12 scie scopus 000602006100001 2-s2.0-85096671540 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article CELL-PROLIFERATION PUTRESCINE PROLINE GROWTH TISSUE METABOLISM colorectal cancer liquid chromatography-mass spectrometry polyamine tumorectomy metabolomics biomarker