Nam, Gi-Hoon Choi, Yoonjeong Kim, Gi Beom Kim, Seohyun Kim, Seong A. Kim, In-San 2024-01-19T16:02:57Z 2024-01-19T16:02:57Z 2021-09-02 2020-12 0935-9648 https://pubs.kist.re.kr/handle/201004/117802 Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are secreted by most cells and contain various bioactive molecules reflecting their cellular origin and mediate intercellular communication. Studies of these exosomal features in tumor pathogenesis have led to the development of therapeutic and diagnostic approaches using exosomes for cancer therapy. Exosomes have many advantages for conveying therapeutic agents such as small interfering RNAs, microRNAs, membrane-associated proteins, and chemotherapeutic compounds; thus, they are considered a prime candidate as a delivery tool for cancer treatment. Since exosomes also provide an optimal microenvironment for the effective function of immunomodulatory factors, exosomes harboring bioactive molecules have been bioengineered as cancer immunotherapies that can effectively activate each stage of the cancer immunity cycle to successfully elicit cancer-specific immunity. This review discusses the advantages of exosomes for treating cancer and the challenges that must be overcome for their successful clinical development. English WILEY-V C H VERLAG GMBH CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS IMMUNE-CHECKPOINT BLOCKADE BLOOD-BRAIN-BARRIER EXTRACELLULAR VESICLES DRUG-DELIVERY DENDRITIC CELLS T-CELLS MEDIATED ENDOCYTOSIS TRANSFERRIN RECEPTOR Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy Article 10.1002/adma.202002440 1 ADVANCED MATERIALS, v.32, no.51 ADVANCED MATERIALS 32 51 scie scopus 000574866400001 2-s2.0-85092066002 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Review CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS IMMUNE-CHECKPOINT BLOCKADE BLOOD-BRAIN-BARRIER EXTRACELLULAR VESICLES DRUG-DELIVERY DENDRITIC CELLS T-CELLS MEDIATED ENDOCYTOSIS TRANSFERRIN RECEPTOR cancer therapeutics characterization and clinical-grade exosomes exosomes extracellular vesicles immunotherapy