Tahk, Dongha Bang, Seokyoung Hyung, Sujin Lim, Jungeun Yu, James Kim, Jinhyun Jeon, Noo Li Kim, Hong Nam 2024-01-19T16:03:28Z 2024-01-19T16:03:28Z 2021-09-02 2020-11-21 1473-0197 https://pubs.kist.re.kr/handle/201004/117834 This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture. English Royal Society of Chemistry CELL-CULTURE FABRICATION HYDROGELS BIOMATERIALS SYSTEMS DEVICES Self-detachable UV-curable polymers for open-access microfluidic platforms Article 10.1039/d0lc00604a 1 Lab on a Chip, v.20, no.22, pp.4215 - 4224 Lab on a Chip 20 22 4215 4224 scie scopus 000588192800008 2-s2.0-85096029251 Biochemical Research Methods Chemistry, Multidisciplinary Chemistry, Analytical Nanoscience & Nanotechnology Instruments & Instrumentation Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Instruments & Instrumentation Article CELL-CULTURE FABRICATION HYDROGELS BIOMATERIALS SYSTEMS DEVICES