Park, Mi Kyung Li, Mei-Xian Yeo, Ingyu Jung, Jaehoon Yoon, Byung-IL Joung, Yoon Ki 2024-01-19T16:03:35Z 2024-01-19T16:03:35Z 2021-09-02 2020-11-15 0144-8617 https://pubs.kist.re.kr/handle/201004/117842 Catechol-conjugated chitosan (CCs), used as tissue adhesive, wound dressing, and hemostatic materials, has been drawing much more attention. However, most CCs tissue adhesives exhibit poor adhesion strength, and few studies on optimization of cohesion and adhesion strength of CCs derivatives have been conducted. This work focused on the balance between cohesion and adhesion strength of catechol-conjugated chitosan (CCs) derivatives via different mechanisms of chemical and enzymatic conjugation. CCs derivatives were characterized regarding its mechanical property, cytotoxicity, platelet adhesion and wound healing test. Mechanical properties could be optimized by the degree of catechol substitution, pH and the presence of oxidizing agent, resulting in that the highest value of adhesive shear strength to the porcine tissue is 64.8 +/- 5.7 kPa. In addition, CCs derivatives exhibit decreased toxicity and promoted in vivo wound healing effects as comparing to a commercially available adhesive (Dermabond (R)). All the results demonstrate that CCs derivatives can be used as well-optimized tissue adhesives as well as a hemostat. English ELSEVIER SCI LTD TISSUE ADHESIVE CROSS-LINKING MUSSEL PROTEIN HYDROGELS BIOADHESIVES COMPONENTS CHEMISTRY HEMOSTATS SEALANTS Balanced adhesion and cohesion of chitosan matrices by conjugation and oxidation of catechol for high-performance surgical adhesives Article 10.1016/j.carbpol.2020.116760 1 CARBOHYDRATE POLYMERS, v.248 CARBOHYDRATE POLYMERS 248 scie scopus 000571218400009 2-s2.0-85088050984 Chemistry, Applied Chemistry, Organic Polymer Science Chemistry Polymer Science Article TISSUE ADHESIVE CROSS-LINKING MUSSEL PROTEIN HYDROGELS BIOADHESIVES COMPONENTS CHEMISTRY HEMOSTATS SEALANTS Surgical adhesive Chitosan Catechol Tyrosinase Adhesion Cohesion