Rahman, Md. Ataur Rahman, MD. Hasanur Hossain, Md. Shahadat Biswas, Partha Islam, Rokibul Uddin, Md Jamal Rahman, Md. Habibur Rhim, Hyewhon 2024-01-19T16:04:15Z 2024-01-19T16:04:15Z 2022-01-10 2020-11 2227-9059 https://pubs.kist.re.kr/handle/201004/117879 Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, cardiovascular disease, diabetes, and malignancies. Recently, natural compounds have come to attention for being able to modulate the autophagy pathway in cancer prevention, although the prospective role of autophagy in cancer treatment is very complex and not yet clearly elucidated. Numerous synthetic chemicals have been identified that modulate autophagy and are favorable candidates for cancer treatment, but they have adverse side effects. Therefore, different phytochemicals, which include natural compounds and their derivatives, have attracted significant attention for use as autophagy modulators in cancer treatment with minimal side effects. In the current review, we discuss the promising role of natural compounds in modulating the autophagy pathway to control and prevent cancer, and provide possible therapeutic options. English MDPI AG Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention Article 10.3390/biomedicines8110517 1 Biomedicines, v.8, no.11 Biomedicines 8 11 Y scie scopus 000593620100001 2-s2.0-85096319099 Biochemistry & Molecular Biology Medicine, Research & Experimental Pharmacology & Pharmacy Biochemistry & Molecular Biology Research & Experimental Medicine Pharmacology & Pharmacy Review MARINE ALKALOID MONANCHOCIDIN SH-SY5Y NEUROBLASTOMA-CELLS ELEMENE INDUCES APOPTOSIS DIETARY FLAVONOID FISETIN ACID-INDUCED APOPTOSIS N-TERMINAL KINASE MAMMALIAN TARGET ALPHA-SYNUCLEIN IN-VITRO MITOCHONDRIAL DYSFUNCTION autophagy cancer phytochemical natural compound treatment