Kim, Eun Young Ahn, Hee-Sung Lee, Min Young Yu, Jiyoung Yeom, Jeonghun Jeong, Hwangkyo Min, Hophil Lee, Hyun Jeong Kim, Kyunggon Ahn, Yong Min 2024-01-19T16:30:28Z 2024-01-19T16:30:28Z 2021-09-02 2020-11 2227-9059 https://pubs.kist.re.kr/handle/201004/117940 Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent course. Recognition of biological markers that could predict and monitor response to drug treatment could personalize clinical decision-making, minimize unnecessary drug exposure, and achieve better outcomes. Four longitudinal plasma samples were collected from each of ten patients with MDD treated with antidepressants for 10 weeks. Plasma proteins were analyzed qualitatively and quantitatively with a nanoflow LC-MS/MS technique. Of 1153 proteins identified in the 40 longitudinal plasma samples, 37 proteins were significantly associated with response/time and clustered into six according to time and response by the linear mixed model. Among them, three early-drug response markers (PHOX2B, SH3BGRL3, and YWHAE) detectable within one week were verified by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS) in the well-controlled 24 patients. In addition, 11 proteins correlated significantly with two or more psychiatric measurement indices. This pilot study might be useful in finding protein marker candidates that can monitor response to antidepressant treatment during follow-up visits within 10 weeks after the baseline visit. English MDPI AG An Exploratory Pilot Study with Plasma Protein Signatures Associated with Response of Patients with Depression to Antidepressant Treatment for 10 Weeks Article 10.3390/biomedicines8110455 1 Biomedicines, v.8, no.11 Biomedicines 8 11 Y scie scopus 000593598300001 2-s2.0-85094615695 Biochemistry & Molecular Biology Medicine, Research & Experimental Pharmacology & Pharmacy Biochemistry & Molecular Biology Research & Experimental Medicine Pharmacology & Pharmacy Article DOPAMINE-BETA-HYDROXYLASE GENERALIZED ESTIMATING EQUATIONS PREANALYTICAL VARIABLES MASS-SPECTROMETRY EFFECTS MODELS SERUM DISORDER GENE BIOMARKERS RISK major depressive disorder longitudinal study LC-MS/MS plasma protein biomarker drug response monitoring multiple reaction monitoring