Jung, Da Seul Son, Yang-Ju Shin, Ji Min Won, Hyo Jun Le, Tam Thi Jung, Sang Hoon Lee, Chang-Ho Nho, Chu Won 2024-01-19T16:30:46Z 2024-01-19T16:30:46Z 2021-09-02 2020-11 1613-4125 https://pubs.kist.re.kr/handle/201004/117959 Scope Metabolic syndrome and obesity are rising worldwide concerns that are accompanied by adverse health consequences. Here, it is hypothesized that the ethanol extract fromGymnaster koraiensis(GK), an edible Korean plant known for its anti-cancer and hepatoprotective properties, could attenuate metabolic syndrome-related symptoms in high-fat dietary-induced obese (DIO) mice. Methods and Results Administration of 100 mg kg(-1)GK extract to DIO mice effectively reduces body and white adipose tissue (WAT) weight. It also reduces cardiovascular disease risk and improves insulin resistance by lowering the fasting blood glucose levels and mitigating oxidative stress and inflammation. Moreover, supplementation with GK causes elevated energy expenditure in WAT by increasing the mitochondrial oxidative capacity and lipid catabolism through upregulated adenosine monophosphate-activated protein kinase (AMPK) signaling. Orlistat is used as a positive control drug due to its widespread use in previous studies. It is found that GK extract causes weight loss, similar to Orlistat, and it additionally shows unique functions, such as upregulation of energy consumption in WAT. Conclusion GK extract treatment prominently reduces obesity and its associated metabolic complications, such as hyperlipidemia, hyperglycemia, and insulin resistance. Hence, It can be used as a promising multi-target functional food that can improve metabolic syndrome-related symptoms. English WILEY INSULIN-RESISTANCE PPAR-GAMMA OBESITY FAT POLYACETYLENE MANAGEMENT PROTEIN ACID Gymnaster KoraiensisExtract Alleviated Metabolic Syndrome Symptoms and Stimulated UCP1-Independent Energy Consumption via AMPK Activation in White Adipose Tissue Article 10.1002/mnfr.202000490 1 MOLECULAR NUTRITION & FOOD RESEARCH, v.64, no.22 MOLECULAR NUTRITION & FOOD RESEARCH 64 22 scie scopus 000579461200001 2-s2.0-85092700942 Food Science & Technology Food Science & Technology Article INSULIN-RESISTANCE PPAR-GAMMA OBESITY FAT POLYACETYLENE MANAGEMENT PROTEIN ACID AMP-activated protein kinase Gymnaster koraiensis metabolic syndrome obesity UCP1-independent energy consumption