Hong, Sung-Chul Ha, Jung-Heun Lee, Jennifer K. Jung, Sang Hoon Kim, Jin-Chul 2024-01-19T16:30:57Z 2024-01-19T16:30:57Z 2021-09-02 2020-11 2072-6643 https://pubs.kist.re.kr/handle/201004/117970 Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used traditionally as an edible herb in Korea. It has been reported to have wound-healing and inhibitory effects against insulin resistance and inflammation. Here, we examined the inhibitory effects of inflammation and ER stress by A. koraiensis extract (AKE) in animal model and human retinal pigmented epithelial (ARPE-19) cells. Oral administration of AKE mitigated DE symptoms, including reduced corneal epithelial thickness, increased the gap between lacrimal gland tissues in experimental animals and decreased tear production. It also inhibited inflammatory responses in the corneal epithelium and lacrimal gland. Consequently, the activation of NF-kappa B was attenuated by the suppression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Moreover, AKE treatment ameliorated TNF-alpha-inducible ocular inflammation and thapsigargin (Tg)-inducible ER stress in animal model and human retinal pigmented epithelial (ARPE-19) cells. These results prove that AKE prevents detrimental functional and histological remodeling on the ocular surface and in the lacrimal gland through inhibition of inflammation and ER stress, suggesting its potential as functional food material for improvement of DES. English MDPI ENDOPLASMIC-RETICULUM STRESS ANTIOXIDANT ACTIVITY TNF-ALPHA KAPPA-B DISEASE MECHANISMS EXPRESSION PATHOPHYSIOLOGY DISRUPTION EPITHELIUM In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface Article 10.3390/nu12113245 1 NUTRIENTS, v.12, no.11 NUTRIENTS 12 11 scie scopus 000594522000001 2-s2.0-85094190804 Nutrition & Dietetics Nutrition & Dietetics Article ENDOPLASMIC-RETICULUM STRESS ANTIOXIDANT ACTIVITY TNF-ALPHA KAPPA-B DISEASE MECHANISMS EXPRESSION PATHOPHYSIOLOGY DISRUPTION EPITHELIUM functional food dry eye Aster koraiensis animal model and human retinal pigmented epithelial (ARPE-19) cells