Kim, Yoon Kyoung Choi, Yoonjeong Nam, Gi-Hoon Kim, In-San 2024-01-19T16:31:46Z 2024-01-19T16:31:46Z 2021-09-02 2020-10-01 0304-3835 https://pubs.kist.re.kr/handle/201004/118019 Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circulation in vivo. In this review, we cover recent approaches and advances made in the field of exosome-mediated delivery of bioactive molecules for cancer therapy and factors that affect the clinical use of exosomes. This review can be used as a guideline for further study in expanding the utility of therapeutic exosomes. English ELSEVIER IRELAND LTD TARGETED EXTRACELLULAR VESICLES TUMOR-DERIVED EXOSOMES DRUG-DELIVERY MEMBRANE-PROTEINS BREAST NANOVESICLES PACLITAXEL PLATFORM CELLS BRAIN Functionalized exosome harboring bioactive molecules for cancer therapy Article 10.1016/j.canlet.2020.05.036 1 CANCER LETTERS, v.489, pp.155 - 162 CANCER LETTERS 489 155 162 scie scopus 000570246700017 2-s2.0-85087500656 Oncology Oncology Review TARGETED EXTRACELLULAR VESICLES TUMOR-DERIVED EXOSOMES DRUG-DELIVERY MEMBRANE-PROTEINS BREAST NANOVESICLES PACLITAXEL PLATFORM CELLS BRAIN Exosome Cancer therapeutics Drug delivery Bioactive molecules