Kang, Mikyung Hong, Jihye Jung, Mungyo Kwon, Sung Pil Song, Seuk Young Kim, Han Young Lee, Ju-Ro Kong, Seokyung Han, Jin Koo, Ja-Hyun Ryu, Ju Hee Lim, Songhyun Sohn, Hee Su Choi, Je-Min Doh, Junsang Kim, Byung-Soo 2024-01-19T16:32:23Z 2024-01-19T16:32:23Z 2021-09-02 2020-10 0935-9648 https://pubs.kist.re.kr/handle/201004/118057 Cancer immunotherapies, including adoptive T cell transfer and immune checkpoint blockades, have recently shown considerable success in cancer treatment. Nevertheless, transferred T cells often become exhausted because of the immunosuppressive tumor microenvironment. Immune checkpoint blockades, in contrast, can reinvigorate the exhausted T cells; however, the therapeutic efficacy is modest in 70-80% of patients. To address some of the challenges faced by the current cancer treatments, here T-cell-membrane-coated nanoparticles (TCMNPs) are developed for cancer immunotherapy. Similar to cytotoxic T cells, TCMNPs can be targeted at tumors via T-cell-membrane-originated proteins and kill cancer cells by releasing anticancer molecules and inducing Fas-ligand-mediated apoptosis. Unlike cytotoxic T cells, TCMNPs are resistant to immunosuppressive molecules (e.g., transforming growth factor-beta 1 (TGF-beta 1)) and programmed death-ligand 1 (PD-L1) of cancer cells by scavenging TGF-beta 1 and PD-L1. Indeed, TCMNPs exhibit higher therapeutic efficacy than an immune checkpoint blockade in melanoma treatment. Furthermore, the anti-tumoral actions of TCMNPs are also demonstrated in the treatment of lung cancer in an antigen-nonspecific manner. Taken together, TCMNPs have a potential to improve the current cancer immunotherapy. English WILEY-V C H VERLAG GMBH ADVERSE EVENTS MELANOMA LYMPHOCYTES DACARBAZINE EXPRESSION BLOCKADE VESICLES SELECTIN ANTIBODY IMMUNITY T-Cell-Mimicking Nanoparticles for Cancer Immunotherapy Article 10.1002/adma.202003368 1 ADVANCED MATERIALS, v.32, no.39 ADVANCED MATERIALS 32 39 scie scopus 000560350700001 2-s2.0-85089476383 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article ADVERSE EVENTS MELANOMA LYMPHOCYTES DACARBAZINE EXPRESSION BLOCKADE VESICLES SELECTIN ANTIBODY IMMUNITY cancer cell-mimicking nanoparticles cytotoxic T-lymphocytes immunotherapy nanomedicine