Kim, Byul Nim Kim, Eunjung Lee, Sunmi Oh, Chunyoung 2024-01-19T16:32:24Z 2024-01-19T16:32:24Z 2021-09-02 2020-10 2227-9717 https://pubs.kist.re.kr/handle/201004/118058 The novel coronavirus disease (COVID-19) poses a severe threat to public health officials all around the world. The early COVID-19 outbreak in South Korea displayed significant spatial heterogeneity. The number of confirmed cases increased rapidly in the Daegu and Gyeongbuk (epicenter), whereas the spread was much slower in the rest of Korea. A two-patch mathematical model with a mobility matrix is developed to capture this significant spatial heterogeneity of COVID-19 outbreaks from 18 February to 24 March 2020. The mobility matrix is taken from the movement data provided by the Korea Transport Institute (KOTI). Some of the essential patch-specific parameters are estimated through cumulative confirmed cases, including the transmission rates and the basic reproduction numbers (local and global). Our simulations show that travel restrictions between the epicenter and the rest of Korea effectively prevented massive outbreaks in the rest of Korea. Furthermore, we explore the effectiveness of several additional strategies for the mitigation and suppression of Covid-19 spread in Korea, such as implementing social distancing and early diagnostic interventions. English MDPI INTERVENTIONS Mathematical Model of COVID-19 Transmission Dynamics in South Korea: The Impacts of Travel Restrictions, Social Distancing, and Early Detection Article 10.3390/pr8101304 1 PROCESSES, v.8, no.10 PROCESSES 8 10 scie scopus 000586197300001 2-s2.0-85093644587 Engineering, Chemical Engineering Article INTERVENTIONS COVID-19 transmission dynamics in South Korea two-patch mathematical model mobility data basic reproduction number cumulative incidence travel restrictions social distancing early diagnostic interventions