Kim, Soon-Young Lee, Eun-Hye Kim, Eun Na Son, Woo-Chan Kim, Yeo Hyang Park, Seung-Yoon Kim, In-San Kim, Jung-Eun 2024-01-19T16:32:44Z 2024-01-19T16:32:44Z 2021-09-02 2020-10 1661-6596 https://pubs.kist.re.kr/handle/201004/118078 The placenta undergoes reconstruction at different times during fetal development to supply oxygen and nutrients required throughout pregnancy. To accommodate the rapid growth of the fetus, small spiral arteries undergo remodeling in the placenta. This remodeling includes apoptosis of endothelial cells that line spiral arteries, which are replaced by trophoblasts of fetal origin. Removal of dead cells is critical during this process. Stabilin-1 (Stab1) and stabilin-2 (Stab2) are important receptors expressed on scavenger cells that absorb and degrade apoptotic cells, and Stab1 is expressed in specific cells of the placenta. However, the role of Stab1 and Stab2 in placental development and maintenance remain unclear. In this study, we assessed Stab1 and Stab2 expression in the placenta and examined the reproductive capacity and placental development using a double-knockout mouse strain lacking both Stab1 and Stab2 (Stab1/2 dKO mice). Most pregnant Stab1/2 dKO female mice did not produce offspring and exhibited placental defects, including decidual hemorrhage and necrosis. Findings of this study offer the first description of the phenotypic characteristics of placentas and embryos of Stab1/2 dKO females during pregnancy, suggesting that Stab1 and Stab2 are involved in placental development and maintenance. English MDPI Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study Article 10.3390/ijms21197235 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.19 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 19 scie scopus 000586567600001 2-s2.0-85091998486 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article Stabilin-1 Stabilin-2 double knockout placenta decidua hemorrhage