Cha, Kwang Hyun Yang, Jung-Seok Kim, Kyung-A Yoon, Kye-Yoon Song, Dae-Geun Erdene-Ochir, Erdenedolgor Kang, Kyungsu Pan, Cheol-Ho Ko, GwangPyo 2024-01-19T16:32:50Z 2024-01-19T16:32:50Z 2021-08-31 2020-10 0963-9969 https://pubs.kist.re.kr/handle/201004/118084 Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation. English ELSEVIER AKKERMANSIA-MUCINIPHILA ENERGY RESTRICTION INFLAMMATION OBESE APPETITE WEIGHT ADULTS DAIRY BIOAVAILABILITY CLASSIFICATION Improvement in host metabolic homeostasis and alteration in gut microbiota in mice on the high-fat diet: A comparison of calcium supplements Article 10.1016/j.foodres.2020.109495 1 FOOD RESEARCH INTERNATIONAL, v.136 FOOD RESEARCH INTERNATIONAL 136 scie scopus 000564550900001 2-s2.0-85087198543 Food Science & Technology Food Science & Technology Article AKKERMANSIA-MUCINIPHILA ENERGY RESTRICTION INFLAMMATION OBESE APPETITE WEIGHT ADULTS DAIRY BIOAVAILABILITY CLASSIFICATION Calcium carbonate Calcium citrate Gut microbiota Metabolic homeostasis In vivo mice experiment