Park, Jung-Won Han, Seong-Beom Hah, Jungwon Lee, Geonhui Kim, Jeong-Ki Kim, Soo Hyun Kim, Dong-Hwee 2024-01-19T16:34:30Z 2024-01-19T16:34:30Z 2021-09-02 2020-09 2072-666X https://pubs.kist.re.kr/handle/201004/118180 Aging is a progressive functional decline in organs and tissues over time and typically represents the accumulation of psychological and social changes in a human being. Diverse diseases, such as cardiovascular, musculoskeletal, and neurodegenerative disorders, are now understood to be caused by aging. While biological assessment of aging mainly focuses on the gradual changes that occur either on the molecular scale, for example, alteration of gene expression and epigenetic modification, or on larger scales, for example, changes in muscle strength and cardiac function, the mechanics that regulates the behavior of individual cells and interactions between the internal elements of cells, are largely missing. In this study, we show that the dynamic features of migrating cells across different human ages could help to establish the underlying mechanism of biological age-dependent cellular functional decline. To determine the relationship between cellular dynamics and human age, we identify the characteristic relationship between cell migration and nuclear motion which is tightly regulated by nucleus-bound cytoskeletal organization. This analysis demonstrates that actomyosin contractility-dependent nuclear motion plays a key role in cell migration. We anticipate this study to provide noble biophysical insights on biological aging in order to precisely diagnose age-related chronic diseases. English MDPI ORGANIZATION NETWORK AGE Biological Aging Modulates Cell Migration via Lamin A/C-Dependent Nuclear Motion Article 10.3390/mi11090801 1 MICROMACHINES, v.11, no.9 MICROMACHINES 11 9 scie scopus 000581310000001 2-s2.0-85090858310 Chemistry, Analytical Nanoscience & Nanotechnology Instruments & Instrumentation Physics, Applied Chemistry Science & Technology - Other Topics Instruments & Instrumentation Physics Article ORGANIZATION NETWORK AGE aging cell motility lamin A C nuclear dynamics