Koo, Jahyun Kim, Sung Bong Choi, Yeon Sik Xie, Zhaoqian Bandodkar, Amay J. Khalifeh, Jawad Yan, Ying Kim, Hojun Pezhouh, Maryam Kherad Doty, Karen Lee, Geumbee Chen, Yu-Yu Lee, Seung Min D'Andrea, Dominic Jung, Kimin Lee, KunHyuck Li, Kan Jo, Seongbin Wang, Heling Kim, Jae-Hwan Kim, Jeonghyun Choi, Sung-Geun Jang, Woo Jin Oh, Yong Suk Park, Inkyu Kwak, Sung Soo Park, Ji-Hyeon Hong, Doosun Feng, Xue Lee, Chi-Hwan Banks, Anthony Leal, Cecilia Lee, Hyuck Mo Huang, Yonggang Franz, Colin K. Ray, Wilson Z. MacEwan, Matthew Kang, Seung-Kyun Rogers, John A. 2024-01-19T17:02:14Z 2024-01-19T17:02:14Z 2021-09-02 2020-08 2375-2548 https://pubs.kist.re.kr/handle/201004/118327 Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin. English AMER ASSOC ADVANCEMENT SCIENCE Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion Article 10.1126/sciadv.abb1093 1 SCIENCE ADVANCES, v.6, no.35 SCIENCE ADVANCES 6 35 N scie scopus 000580595700013 2-s2.0-85090873304 Multidisciplinary Sciences Science & Technology - Other Topics Article DOXORUBICIN BIOCOMPATIBILITY ALLOY-625 TISSUE