Lu, Huan-Jun Thien-Luan Nguyen Hong, Gyu-Sang Pak, Sungmin Kim, Hyesu Kim, Hyungsup Kim, Dong-Yoon Kim, Sung-Yon Shen, Yiming Ryu, Pan Dong Lee, Mi-Ock Oh, Uhtaek 2024-01-19T17:03:40Z 2024-01-19T17:03:40Z 2021-09-05 2020-07-01 0021-9738 https://pubs.kist.re.kr/handle/201004/118410 The baroreceptor reflex is a powerful neural feedback that regulates arterial pressure (AP). Mechanosensitive channels transduce pulsatile AP to electrical signals in baroreceptors. Here we show that tentonin 3 (TTN3/TMEM150C), a cation channel activated by mechanical strokes, is essential for detecting AP changes in the aortic arch. TTN3 was expressed in nerve terminals in the aortic arch and nodose ganglion (NG) neurons. Genetic ablation of Ttn3 induced ambient hypertension, tachycardia, AP fluctuations, and impaired baroreflex sensitivity. Chemogenetic silencing or activation of Ttn3(+) neurons in the NG resulted in an increase in AP and heart rate, or vice versa. More important, overexpression of Ttn3 in the NG of Ttn3(-/-) mice reversed the cardiovascular changes observed in Ttn3(-/-) mice. We conclude that TTN3 is a molecular component contributing to the sensing of dynamic AP changes in baroreceptors. English AMER SOC CLINICAL INVESTIGATION INC BARORECEPTOR REFLEX CARDIOVASCULAR-RESPONSES BAROREFLEX SENSITIVITY SENSORY NEURONS WHOLE-BRAIN ACTIVATION CHANNELS VARIABILITY MICE POLYMERIZATION Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch Article 10.1172/JCI133798 1 JOURNAL OF CLINICAL INVESTIGATION, v.130, no.7, pp.3671 - 3683 JOURNAL OF CLINICAL INVESTIGATION 130 7 3671 3683 scie scopus 000579366200004 2-s2.0-85087533086 Medicine, Research & Experimental Research & Experimental Medicine Article BARORECEPTOR REFLEX CARDIOVASCULAR-RESPONSES BAROREFLEX SENSITIVITY SENSORY NEURONS WHOLE-BRAIN ACTIVATION CHANNELS VARIABILITY MICE POLYMERIZATION Tentonin 3 TTN3 Mechanosensation Mechanotransduction Baroreceptor