Jo, Beom-Geun Bong, Sim-Kyu Jegal, Jonghwan Kim, Su-Nam Yang, Min Hye 2024-01-19T17:03:57Z 2024-01-19T17:03:57Z 2022-01-10 2020-07 1934-578X https://pubs.kist.re.kr/handle/201004/118426 The current study was undertaken to isolate and identify anti-inflammatory and antiallergic active compounds in the ethyl acetate and butanol fractions of an ethanolic extract of the aerial parts of Sid/era ehavraOsme (SCAE). A new maltol glucoside, maltol 3-(6 ''-(2-(E)-butenoyl)-glucoside) and benzoic acid, daphnoretin (a coumarin), 6 flavonoids (apigenin, genk-wanin, taxifolin, apigenin 7-O-glucoside, luteolin 7-O-sambubioside, genkwanin 5-O-glucoside), and 2 lignans (matairesinoside and lariciresinol) were isolated from SCAE by chromatographic separation. Their chemical structures were elucidated by analyzing spectroscopic data, including 1-dimensional and 2-dimensional nuclear magnetic resonance (Fig1). Maltol 3-(6 ''-(2-(E)-butenoyl)-glucoside) significandy inhibited beta-hexosaminidase release by 85.5% in immunoglobulin E and dinitrophenyl/bovine serum albumin (DNP/BSA)induced RBL-2H3 cells. Benzoic acid from S. chamaejasme inhibited beta-hexosaminidase release (by 80.2%) in IgE and DNP/BSA-induced RBI; 2H3 cells and interleukin-4 messenger ribonucleic acid expression (by 21.9% inhibition) in propidium iodide-induced RBL-2H3 cells. English SAGE PUBLICATIONS INC FLAVONOIDS COUMARINS ANTIHISTAMINES RELEASE EXTRACT ROOTS Antiallergic Effects of Phenolic Compounds Isolated From Stellera chamaejasme on RBL-2H3 Cells Article 10.1177/1934578X20942352 1 NATURAL PRODUCT COMMUNICATIONS, v.15, no.7, pp.1 - 7 NATURAL PRODUCT COMMUNICATIONS 15 7 1 7 scie scopus 000555354700001 2-s2.0-85089141612 Chemistry, Medicinal Food Science & Technology Pharmacology & Pharmacy Food Science & Technology Article FLAVONOIDS COUMARINS ANTIHISTAMINES RELEASE EXTRACT ROOTS maltol 3-O-(4 &apos -O-trans-2-butenoate)-beta-D-glucopyranosidex Stellera chamaejasme Interleukin-4 beta-hexosamididase RBL-2H3 cells