Park, Wooram Cho, Soojeong Kang, Dongkyu Han, Jun-Hyeok Park, Jung-Hoon Lee, Byeongdu Lee, Joonseok Kim, Dong-Hyun 2024-01-19T17:04:03Z 2024-01-19T17:04:03Z 2021-09-05 2020-07 2192-2640 https://pubs.kist.re.kr/handle/201004/118433 Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobicClostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF4:Tb,Ce@NaGdF(4)core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. An anaerobic oncolytic bacterium (C. novyi-NT) therapy is combined to treat the hypoxic central tumor tissues. Photosensitizer-coated NSs (PS-NSs) andC. novyi-NT spores are emulsified with clinically available ethiodized oil (Lipiodol) to be the nano-bio therapeutic emulsion and injected into the tumor with computed tomography image guidance. The distribution of nano-bio therapeutic emulsion, including PS-NSs and anaerobicC. novyi-NT spores in the tumor site, is confirmed by both X-ray andT(1)-weighted magnetic resonance imaging. Following the image-guided X-ray PDT and anaerobicC. novyi- NT combination treatment, apoptotic cell death in cancer tissues, including both peripheral and central tumor regions, is significantly higher than in the control groups. This combination therapy approach using a nano-bio therapeutic emulsion is expected to overcome the limitations of conventional cancer therapy, resulting in increased cancer-therapeutic efficacy. English WILEY DEEP PHOTODYNAMIC THERAPY PROSTATE-CANCER PHOTOTHERMAL THERAPY CHECKPOINT BLOCKADE NANOPARTICLES DOXORUBICIN EFFICACY LIPIODOL CHEMOEMBOLIZATION NANOCRYSTALS Tumor Microenvironment Targeting Nano-Bio Emulsion for Synergistic Combinational X-Ray PDT with Oncolytic Bacteria Therapy Article 10.1002/adhm.201901812 1 ADVANCED HEALTHCARE MATERIALS, v.9, no.13 ADVANCED HEALTHCARE MATERIALS 9 13 scie scopus 000539765000001 2-s2.0-85086240976 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Article DEEP PHOTODYNAMIC THERAPY PROSTATE-CANCER PHOTOTHERMAL THERAPY CHECKPOINT BLOCKADE NANOPARTICLES DOXORUBICIN EFFICACY LIPIODOL CHEMOEMBOLIZATION NANOCRYSTALS bacteriolytic therapy nano-bio emulsions scintillating nanoparticles tumor microenvironments X-ray photodynamic therapy (PDT)