Han, Sungmin Park, Jinyoung Choi, Won Seok Youn, Inchan 2024-01-19T17:04:27Z 2024-01-19T17:04:27Z 2021-09-05 2020-07 2076-3425 https://pubs.kist.re.kr/handle/201004/118457 Ultrasound stimulation (US) is reported to be a safe and useful technology for improving injured nerve regeneration. However, the intracellular mechanisms underlying its stimulatory effects are only partially understood. Mammalian target of rapamycin (mTOR) signaling is involved in neuronal survival and axonal outgrowth. In this study, we investigated the effect of US on regeneration of injured dorsal root ganglion (DRG) neurons and activation of the mTOR pathway. We showed that US significantly increased neurite regeneration and enhanced mTOR activation. Moreover, the expression of growth-associated protein-43 (GAP-43), a crucial factor for axonal outgrowth and regeneration in neurons, was significantly increased by US. These data suggest that US-induced neurite regeneration is mediated by upregulation of mTOR activity, which promotes the regeneration of injured DRG neurons. English MDPI PERIPHERAL-NERVE REGENERATION LOW-INTENSITY-ULTRASOUND GLYCOLIC ACID) CONDUITS SCIATIC-NERVE OUTGROWTH NEUROMODULATION PTEN/MTOR LASER Ultrasound Stimulation Increases Neurite Regeneration in Injured Dorsal Root Ganglion Neurons through Mammalian Target of Rapamycin Activation Article 10.3390/brainsci10070409 1 BRAIN SCIENCES, v.10, no.7 BRAIN SCIENCES 10 7 scie scopus 000554088400001 2-s2.0-85087398841 Neurosciences Neurosciences & Neurology Article PERIPHERAL-NERVE REGENERATION LOW-INTENSITY-ULTRASOUND GLYCOLIC ACID) CONDUITS SCIATIC-NERVE OUTGROWTH NEUROMODULATION PTEN/MTOR LASER ultrasound stimulation neurite regeneration mammalian target of rapamycin dorsal root ganglion