Jeena, M. T. Lee, Seokyoung Barui, Ayan Kumar Jin, Seongeon Cho, Yuri Hwang, Suk-Won Kim, Sehoon Ryu, Ja-Hyoung 2024-01-19T17:30:43Z 2024-01-19T17:30:43Z 2021-09-04 2020-06-11 1359-7345 https://pubs.kist.re.kr/handle/201004/118519 The design of peptide-based therapeutics is generally based on the replacement ofl-amino acids withd-isomers to obtain improved therapeutic efficiency. However,d-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity in bothd- andl-isomeric forms. This outcome is in contrast to the general observation considering higher therapeutic efficiencies ofd-isomers compared withl-analogues. This suggests thatl-peptides overcome proteolytic degradation during intra-mitochondrial self-assembly bothin vitroandin vivo. English ROYAL SOC CHEMISTRY D-AMINO ACIDS CELLULAR UPTAKE DELIVERY BIODISTRIBUTION Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides Article 10.1039/d0cc02029j 1 CHEMICAL COMMUNICATIONS, v.56, no.46, pp.6265 - 6268 CHEMICAL COMMUNICATIONS 56 46 6265 6268 scie scopus 000541419600017 2-s2.0-85086346489 Chemistry, Multidisciplinary Chemistry Article D-AMINO ACIDS CELLULAR UPTAKE DELIVERY BIODISTRIBUTION