Han, Hyounkoo Kim, Doyeon Jang, Yongho Seo, Minkyu Kim, Kwangmeyung Lee, Jong Bum Kim, Hyuncheol 2024-01-19T17:30:47Z 2024-01-19T17:30:47Z 2021-09-05 2020-06-10 0168-3659 https://pubs.kist.re.kr/handle/201004/118523 Nanotechnology-based combination therapies, especially chemo-gene therapy, have been spotlighted as promising alternatives for cancer therapy. However, only a small amount of systemically administered nanomedicines reach the tumor site by the enhanced permeability and retention (EPR) effect, resulting in the limited therapeutic efficacy. Furthermore, the design of ideal drug delivery system for chemo-gene therapy has been impeded by the chemical and physical differences between nucleic acids and chemotherapeutics. Herein, we report a precisely designed nanocomplex which exhibits a focused ultrasound (FU)-responsive release and enhanced accumulation of released therapeutics to tumor site. After the nanocomplex composed of siRNA nanoparticles (siRNA-NP) and chemotherapeutics-loaded microbubbles was systemically injected, the nanocomplex was collapsed around the tumor tissue by FU exposure, and both siRNA-NP and chemotherapeutics were penetrated the dense extracellular matrix (ECM) of tumor site, leading to the enhanced chemo-gene therapeutic efficacy. The two-in-one nanocomplex is expected as a promising platform for combination therapy that can enhance the therapeutic efficiency of combination drugs at the cell and/or tissue levels with high drug loading ratio. English ELSEVIER SURFACE-PROPERTIES TUMOR-DIAGNOSIS BREAST-CANCER IN-VIVO SIRNA PACLITAXEL DELIVERY DRUG NANOPARTICLES PENETRATION Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy Article 10.1016/j.jconrel.2020.03.041 1 JOURNAL OF CONTROLLED RELEASE, v.322, pp.346 - 356 JOURNAL OF CONTROLLED RELEASE 322 346 356 scie scopus 000537134400002 2-s2.0-85082687938 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article SURFACE-PROPERTIES TUMOR-DIAGNOSIS BREAST-CANCER IN-VIVO SIRNA PACLITAXEL DELIVERY DRUG NANOPARTICLES PENETRATION Focused ultrasound Nanocomplex Chemo-gene therapy Sonoporation effect Mechanical effect