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<dcvalue element="contributor" qualifier="author">Ferguson,&#x20;Fleur&#x20;M.</dcvalue>
<dcvalue element="contributor" qualifier="author">Nabet,&#x20;Behnam</dcvalue>
<dcvalue element="contributor" qualifier="author">Raghavan,&#x20;Srivatsan</dcvalue>
<dcvalue element="contributor" qualifier="author">Liu,&#x20;Yan</dcvalue>
<dcvalue element="contributor" qualifier="author">Leggett,&#x20;Alan&#x20;L.</dcvalue>
<dcvalue element="contributor" qualifier="author">Kuljanin,&#x20;Miljan</dcvalue>
<dcvalue element="contributor" qualifier="author">Kalekar,&#x20;Radha&#x20;L.</dcvalue>
<dcvalue element="contributor" qualifier="author">Yang,&#x20;Annan</dcvalue>
<dcvalue element="contributor" qualifier="author">He,&#x20;Shuning</dcvalue>
<dcvalue element="contributor" qualifier="author">Wang,&#x20;Jinhua</dcvalue>
<dcvalue element="contributor" qualifier="author">Ng,&#x20;Raymond&#x20;W.&#x20;S.</dcvalue>
<dcvalue element="contributor" qualifier="author">Sulahian,&#x20;Rita</dcvalue>
<dcvalue element="contributor" qualifier="author">Li,&#x20;Lianbo</dcvalue>
<dcvalue element="contributor" qualifier="author">Poulin,&#x20;Emily&#x20;J.</dcvalue>
<dcvalue element="contributor" qualifier="author">Huang,&#x20;Ling</dcvalue>
<dcvalue element="contributor" qualifier="author">Koren,&#x20;Jost</dcvalue>
<dcvalue element="contributor" qualifier="author">Dieguez-Martinez,&#x20;Nora</dcvalue>
<dcvalue element="contributor" qualifier="author">Espinosa,&#x20;Sergio</dcvalue>
<dcvalue element="contributor" qualifier="author">Zeng,&#x20;Zhiyang</dcvalue>
<dcvalue element="contributor" qualifier="author">Corona,&#x20;Cesear&#x20;R.</dcvalue>
<dcvalue element="contributor" qualifier="author">Vastall,&#x20;James&#x20;D.</dcvalue>
<dcvalue element="contributor" qualifier="author">Ohi,&#x20;Ryoma</dcvalue>
<dcvalue element="contributor" qualifier="author">Sim,&#x20;Tae&#x20;Bo</dcvalue>
<dcvalue element="contributor" qualifier="author">Kim,&#x20;Nam&#x20;Doo</dcvalue>
<dcvalue element="contributor" qualifier="author">Harshbarger,&#x20;Wayne</dcvalue>
<dcvalue element="contributor" qualifier="author">Lizcano,&#x20;Jose&#x20;M.</dcvalue>
<dcvalue element="contributor" qualifier="author">Robers,&#x20;Matthew&#x20;B.</dcvalue>
<dcvalue element="contributor" qualifier="author">Muthaswamy,&#x20;Senthil</dcvalue>
<dcvalue element="contributor" qualifier="author">Lin,&#x20;Charles&#x20;Y.</dcvalue>
<dcvalue element="contributor" qualifier="author">Look,&#x20;A.&#x20;Thomas</dcvalue>
<dcvalue element="contributor" qualifier="author">Haigis,&#x20;Kevin&#x20;M.</dcvalue>
<dcvalue element="contributor" qualifier="author">Mancias,&#x20;Joseph&#x20;D.</dcvalue>
<dcvalue element="contributor" qualifier="author">Wolpin,&#x20;Brian&#x20;M.</dcvalue>
<dcvalue element="contributor" qualifier="author">Aguirre,&#x20;Andrew&#x20;J.</dcvalue>
<dcvalue element="contributor" qualifier="author">Hahn,&#x20;William&#x20;C.</dcvalue>
<dcvalue element="contributor" qualifier="author">Westover,&#x20;Kenneth&#x20;D.</dcvalue>
<dcvalue element="contributor" qualifier="author">Gray,&#x20;Nathanael&#x20;S.</dcvalue>
<dcvalue element="date" qualifier="accessioned">2024-01-19T17:31:17Z</dcvalue>
<dcvalue element="date" qualifier="available">2024-01-19T17:31:17Z</dcvalue>
<dcvalue element="date" qualifier="created">2022-01-25</dcvalue>
<dcvalue element="date" qualifier="issued">2020-06</dcvalue>
<dcvalue element="identifier" qualifier="issn">1552-4450</dcvalue>
<dcvalue element="identifier" qualifier="uri">https:&#x2F;&#x2F;pubs.kist.re.kr&#x2F;handle&#x2F;201004&#x2F;118547</dcvalue>
<dcvalue element="description" qualifier="abstract">Doublecortin&#x20;like&#x20;kinase&#x20;1&#x20;(DCLK1)&#x20;is&#x20;an&#x20;understudied&#x20;kinase&#x20;that&#x20;is&#x20;upregulated&#x20;in&#x20;a&#x20;wide&#x20;range&#x20;of&#x20;cancers,&#x20;including&#x20;pancreatic&#x20;ductal&#x20;adenocarcinoma&#x20;(PDAC).&#x20;However,&#x20;little&#x20;is&#x20;known&#x20;about&#x20;its&#x20;potential&#x20;as&#x20;a&#x20;therapeutic&#x20;target.&#x20;We&#x20;used&#x20;chemoproteomic&#x20;profiling&#x20;and&#x20;structure-based&#x20;design&#x20;to&#x20;develop&#x20;a&#x20;selective,&#x20;in&#x20;vivo-compatible&#x20;chemical&#x20;probe&#x20;of&#x20;the&#x20;DCLK1&#x20;kinase&#x20;domain,&#x20;DCLK1-IN-1.&#x20;We&#x20;demonstrate&#x20;activity&#x20;of&#x20;DCLK1-IN-1&#x20;against&#x20;clinically&#x20;relevant&#x20;patient-derived&#x20;PDAC&#x20;organoid&#x20;models&#x20;and&#x20;use&#x20;a&#x20;combination&#x20;of&#x20;RNA-sequencing,&#x20;proteomics&#x20;and&#x20;phosphoproteomics&#x20;analysis&#x20;to&#x20;reveal&#x20;that&#x20;DCLK1&#x20;inhibition&#x20;modulates&#x20;proteins&#x20;and&#x20;pathways&#x20;associated&#x20;with&#x20;cell&#x20;motility&#x20;in&#x20;this&#x20;context.&#x20;DCLK1-IN-1&#x20;will&#x20;serve&#x20;as&#x20;a&#x20;versatile&#x20;tool&#x20;to&#x20;investigate&#x20;DCLK1&#x20;biology&#x20;and&#x20;establish&#x20;its&#x20;role&#x20;in&#x20;cancer.</dcvalue>
<dcvalue element="language" qualifier="none">English</dcvalue>
<dcvalue element="publisher" qualifier="none">Nature&#x20;Publishing&#x20;Group</dcvalue>
<dcvalue element="title" qualifier="none">Discovery&#x20;of&#x20;a&#x20;selective&#x20;inhibitor&#x20;of&#x20;doublecortin&#x20;like&#x20;kinase&#x20;1</dcvalue>
<dcvalue element="type" qualifier="none">Article</dcvalue>
<dcvalue element="identifier" qualifier="doi">10.1038&#x2F;s41589-020-0506-0</dcvalue>
<dcvalue element="description" qualifier="journalClass">1</dcvalue>
<dcvalue element="identifier" qualifier="bibliographicCitation">Nature&#x20;Chemical&#x20;Biology,&#x20;v.16,&#x20;no.6,&#x20;pp.635&#x20;-&#x20;643</dcvalue>
<dcvalue element="citation" qualifier="title">Nature&#x20;Chemical&#x20;Biology</dcvalue>
<dcvalue element="citation" qualifier="volume">16</dcvalue>
<dcvalue element="citation" qualifier="number">6</dcvalue>
<dcvalue element="citation" qualifier="startPage">635</dcvalue>
<dcvalue element="citation" qualifier="endPage">643</dcvalue>
<dcvalue element="description" qualifier="isOpenAccess">N</dcvalue>
<dcvalue element="description" qualifier="journalRegisteredClass">scie</dcvalue>
<dcvalue element="description" qualifier="journalRegisteredClass">scopus</dcvalue>
<dcvalue element="identifier" qualifier="wosid">000523953900003</dcvalue>
<dcvalue element="identifier" qualifier="scopusid">2-s2.0-85083218230</dcvalue>
<dcvalue element="relation" qualifier="journalWebOfScienceCategory">Biochemistry&#x20;&amp;&#x20;Molecular&#x20;Biology</dcvalue>
<dcvalue element="relation" qualifier="journalResearchArea">Biochemistry&#x20;&amp;&#x20;Molecular&#x20;Biology</dcvalue>
<dcvalue element="type" qualifier="docType">Article</dcvalue>
<dcvalue element="subject" qualifier="keywordPlus">PROTEIN-PHOSPHORYLATION</dcvalue>
<dcvalue element="subject" qualifier="keywordPlus">LARGE-SCALE</dcvalue>
<dcvalue element="subject" qualifier="keywordPlus">EXPRESSION</dcvalue>
<dcvalue element="subject" qualifier="keywordPlus">CELLS</dcvalue>
<dcvalue element="subject" qualifier="keywordPlus">SITE</dcvalue>
<dcvalue element="subject" qualifier="keywordPlus">ATP</dcvalue>
</dublin_core>
