Lee, Seungjun Roh, Seong Min Lee, Eunji Park, Yejin Lee, Byung Chul Kwon, Youngeun Kim, Hye Jin Kim, Jinsik 2024-01-19T17:32:06Z 2024-01-19T17:32:06Z 2021-09-04 2020-06 1424-8220 https://pubs.kist.re.kr/handle/201004/118595 Since separation of target biomolecules is a crucial step for highly sensitive and selective detection of biomolecules, hence, various technologies have been applied to separate biomolecules, such as deoxyribonucleic acid (DNA), protein, exosome, virus, etc. Among the various technologies, dielectrophoresis (DEP) has the significant advantage that the force can provide two different types of forces, attractive and repulsive DEP force, through simple adjustment in frequency or structure of microfluidic chips. Therefore, in this review, we focused on separation technologies based on DEP force and classified various separation technologies. First, the importance of biomolecules, general separation methods and various forces including DEP, electrophoresis (EP), electrothermal flow (ETF), electroosmosis (EO), magnetophoresis, acoustophoresis (ACP), hydrodynamic, etc., was described. Then, separating technologies applying only a single DEP force and dual force, moreover, applying other forces simultaneously with DEP force were categorized. In addition, advanced technologies applying more than two different kinds of forces, namely complex force, were introduced. Overall, we critically reviewed the state-of-the-art of converged various forces for detection of biomolecules with novelty of DEP. English Multidisciplinary Digital Publishing Institute (MDPI) Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications Article 10.3390/s20113242 1 Sensors, v.20, no.11 Sensors 20 11 Y scie scopus 000552737900235 2-s2.0-85086140684 Chemistry, Analytical Engineering, Electrical & Electronic Instruments & Instrumentation Chemistry Engineering Instruments & Instrumentation Review EXTRACELLULAR VESICLES CONTINUOUS SEPARATION CIRCULATING EXOSOMES CELLS DNA SEDIMENTATION NANOPARTICLES FILTRATION PLASMA SPEED biomolecule separation dielectrophoresis electrophoresis acoustophoretic electroosmotic flow force magnetophoretic force electrokinetic force hydrodynamic force optical trapping force