Chung, Taek Rhee, Hyungjin Nahm, Ji Hae Jeon, Youngsic Yoo, Jeong Eun Kim, Young-Joo Han, Dai Hoon Park, Young Nyun 2024-01-19T17:32:07Z 2024-01-19T17:32:07Z 2021-09-04 2020-06 1365-182X https://pubs.kist.re.kr/handle/201004/118596 Background: Intrahepatic cholangiocarcinoma (iCCA) is subclassified into mass-forming (MF), periductal-infiltrative (PI), and mixed types grossly; however, their clinicopathological significance remains controversial. Methods: Clinicopathological characteristics of iCCA gross types were analysed according to histopathological type (small-duct, large-duct, indeterminate) or cholangiolocellular differentiation trait (CDT) in 108 iCCAs. The expression levels of inflammation-marker (CRP, FGB) and proliferation-marker (phospho-ERK1/2, Ki-67) were evaluated by immunohistochemistry. Results: There were 87 MF, 8 PI, and 13 mixed-gross type. Small-duct-type (39, 44.8%) and CDT (19, 21.8%) were found only in MF-gross type. The inflammation-marker expression was higher in MF-type than in PI- and mixed-gross types (P = 0.023). It was high in small-duct-type, middle in indeterminatetype, and low in large-duct-type (P = 0.015), and iCCAs with CDT showed higher inflammation-marker expression compared to those without (P < 0.001). Proliferation-marker expression did not differ according to gross type; however it was lower in iCCA with CDT compared to those without (P = 0.004). Subgrouping of the gross type according to histopathological type or CDT revealed that MF-type with small-duct-type or CDT had better overall survival compared to the others (P < 0.05). Conclusion: MF-type iCCA is more heterogeneous than other gross types. High inflammation-marker/ low proliferation-marker expression in MF-type with CDT or small-duct-type may be related to a good outcome. English ELSEVIER SCI LTD PROGNOSTIC-FACTORS CLASSIFICATION PATHOGENESIS CARCINOMA FEATURES Clinicopathological characteristics of intrahepatic cholangiocarcinoma according to gross morphologic type: cholangiolocellular differentiation traits and inflammation-and proliferation-phenotypes Article 10.1016/j.hpb.2019.10.009 1 HPB, v.22, no.6, pp.864 - 873 HPB 22 6 864 873 scie scopus 000541536400007 2-s2.0-85075362447 Gastroenterology & Hepatology Surgery Gastroenterology & Hepatology Surgery Article PROGNOSTIC-FACTORS CLASSIFICATION PATHOGENESIS CARCINOMA FEATURES