Maccioni, Paola Lorrai, Irene Fara, Federica Carai, Mauro A. M. Gessa, Gian Luigi Chin, Young-Won Lee, Jung Hwan Kwon, Hak Cheol Corelli, Federico Colombo, Giancarlo 2024-01-19T17:33:25Z 2024-01-19T17:33:25Z 2021-09-05 2020-05 0735-0414 https://pubs.kist.re.kr/handle/201004/118669 Aims: Treatment with saikosaponin A (SSA)-an ingredient of the medicinal herb, Bupleurum falcatum-has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats. Methods: Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik (R) in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B-2 (SSB2) and saikosaponin B-4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.). Results: Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective. Conclusions: The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential. English OXFORD UNIV PRESS BUPLEURUM-FALCATUM ACTIVE INGREDIENT POTENTIAL USE RECEPTOR REINSTATEMENT AGONISTS SEEKING MODEL Differential Effects of Saikosaponins A, B-2, B-4, C and D on Alcohol and Chocolate Self-Administration in Rats Article 10.1093/alcalc/agaa049 1 ALCOHOL AND ALCOHOLISM, v.55, no.4, pp.367 - 373 ALCOHOL AND ALCOHOLISM 55 4 367 373 scie ssci scopus 000544149800009 2-s2.0-85092026599 Substance Abuse Substance Abuse Article BUPLEURUM-FALCATUM ACTIVE INGREDIENT POTENTIAL USE RECEPTOR REINSTATEMENT AGONISTS SEEKING MODEL 사이코사포닌닌 시호호 알코올 탐닉닉 초코렛 탐닉닉 한-이태리 공동연구구